Intensity Modulated Radiation and Volumetric Modulated Arc Therapies in Breast Cancer

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Saddik May Z.; F. Hassan Fatiheea

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Journal Paper

Paper Information

Journal: JOURNAL OF MEDICINAL AND CHEMICAL SCIENCES Year:2023 | Volume:6 | Issue:9 Page(s): 1925-1934

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Title

Intensity Modulated Radiation and Volumetric Modulated Arc Therapies in Breast Cancer

Author(s)

Saddik May Z. | F. Hassan Fatiheea | Issue Writer Certificate

Keywords

breast cancer

dosimetric

Intensity modulated radiation therapy

volumetric modulated arc therapy

Abstract

Background: Breast cancer is the most common malignant neoplasm in women, accounting for 25% of all cancers. Radiotherapy is one of the safest methods compared with other treatments.Methods: In this study, 8 patients with left breast cancer underwent the radiation therapy. After simulating the tomographic data of breast cancer patients, treatment planning was performed in the treatment planning system, and then the clinical target volume and the planned target volume were determined.Results: The mean CI (1.162 ± 0.011) in Intensity Modulated Radiation Therapy (IMRT) was significantly lower than CI (1.173 ± 0.28) in Volumetric Arc Radiation Therapy (VMAT) (P ≤ 0.02), indicates that IMRT technique had lower CI which means better dose conformity within the PTV. Also, the mean HI (0.696 ± 0.333) in VMAT was significant compared to IMRT, the mean HI (0.558 ± 0.288) (P ≤ 0.04), the results on better PTV dose distribution by using VMAT technique. Planning target volume (PTV) was consistent with indicators and PTV coverage value (97.563 ± 1.471) in IMRT and (96.677 ± 1.018) in VMAT, means that the PTV coverage was better by using IMRT technique rather than VMAT. The mean dose to left breast was (42.118 ± 0464) prescribed dose. Ref. vol. CC, D2%, and D98% were received (736.898 ± 235.140), (4618.931 ± 107.658), and (3765.475 ± 71.195), respectively.Conclusion: IMRT method is one of the new cancer treatment techniques that in comparison with other methods by accurately targeting cancer cells and tumors, it has the least impact on healthy tissues and reduces the side effects as much as possible.

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