Evaluation of Antihypoxic Activities of Feijoa Sellowiana, Nepeta Pogonosperma and Cucumis Melo in Mice

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Barani Amin; Motafeghi Farzaneh; Eghbali Mohammad; Mansourian Dorrin; Mirzaalilou Sina; Dadollahi Sarab Pourya; Ebrahimzadeh Mohammad Ali

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2023 | Volume:33 | Issue:226 Page(s): 17-27

Download Full-Text

Persian Verion

View:

Download:

Cites:

Information Journal Paper

Title

Evaluation of Antihypoxic Activities of Feijoa Sellowiana, Nepeta Pogonosperma and Cucumis Melo in Mice

Author(s)

Keywords

asphyctic hypoxia

haemic hypoxia

circulatory hypoxia

Feijoa sellowiana

Nepeta pogonosperma

Cucumis melo

Abstract

Background and purpose: Hypoxia can lead to body function impairment and may cause a variety of physiological abnormalities. Hypoxia is linked to the pathology of acute mountain sickness, cardiovascular disease, and stroke, and is the leading cause of death in many countries. Feijoa sellowiana, Nepeta pogonosperma, and Cucumis melo are plants with good antioxidant activities. Materials and methods: Protective effects of F. sellowiana, N. pogonosperma fruits and C. melo aerial parts against hypoxia-induced lethality in mice were evaluated by three experimental models of hypoxia, including asphyctic, haemic, and circulatory models. Results: F. sellowiana, and N. pogonosperma extracts had good protective effects and increased the survival time of male mice even at their lowest doses, 31. 25 and 62. 5 mg/kg. In all the models, they were effective at low doses and showed a similar degree of efficacy as propranolol and phenytoin, which were used as positive controls. C. melo fruit extract showed a weak effect in these tests. It was effective only in the dose of 250 mg/kg in blood circulatory model of hypoxia. Conclusion: Extracts showed very good protective effects against hypoxia in all the hypoxic models. Even at low doses, they were able to show the same activity of positive controls. It seems that these plants have a good potential for the treatment of hypoxic conditions.

Multimedia

No record.

Cites

References