Synthesis of novel 2-(alkyl/arylamino)-2-oxo-1-(quinolin-4-yl)ethyl cinnamates through three-component reaction between an isocyanide, quinoline-4-carbaldehyde and cinnamic acid derivatives

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Taran Jafar; Ramazani Ali

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Journal Paper

Paper Information

Journal: Journal of Medicinal and Pharmaceutical Chemistry Research Year:621 | Volume: | Issue: Page(s): 319-329

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Information Journal Paper

Title

Synthesis of novel 2-(alkyl/arylamino)-2-oxo-1-(quinolin-4-yl)ethyl cinnamates through three-component reaction between an isocyanide, quinoline-4-carbaldehyde and cinnamic acid derivatives

Author(s)

Taran Jafar | Ramazani Ali | Issue Writer Certificate

Keywords

Multicomponent reactions (MCRs)Q4

Passerini reactionsQ4

Quinoline-4-carbaldehydeQ4

IsocyanideQ4

Cinnamic acid derivativesQ4

Abstract

Passerini reactions of an Isocyanide, Quinoline-4-carbaldehyde, and Cinnamic acid derivatives in water proceed at room temperature giving 2-(alkyl/aryl amino)-2-oxo-1-(quinolin-4-yl)ethyl cinnamate derivatives in quantitative yield. The reactions are one-pot, and the products did not require any purification. This procedure offers significant advantages such as operational simplicity, mild reaction conditions, enhanced rates, cleaner reaction profiles, ease of isolation of products, and H2O as a medium, making it a valuable protocol for synthesizing these compounds.

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