Clinical Characteristics and 8-year Survival Rate in Advanced Ovarian Cancer Following Neoadjuvant Chemotherapy: A Single Center Experience

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOUSAVI AZAMSADAT; AKHAVAN SETAREH; SHEIKHHASANI SHAHRZAD; ZAMANI NARGES; REZAYOF ELAHE; ESMAILZADEH AREZOO

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Red Crescent Medical Journal Year:2022 | Volume:24 | Issue:10 Page(s): 0-0

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Clinical Characteristics and 8-year Survival Rate in Advanced Ovarian Cancer Following Neoadjuvant Chemotherapy: A Single Center Experience

Author(s)

Keywords

Advanced ovarian cancer

Epithelial ovarian cancer

Neoadjuvant chemotherapy

Survival rate

Abstract

Background: More than 75% of Epithelial ovarian cancer (EOC) cases are diagnosed in advanced stages, which is associated with tumor recurrence and chemotherapy resistance. So far, to the best of our knowledge, a similar study has not been conducted in Iran to investigate the clinical characteristics and Survival rate of these patients treated with Neoadjuvant chemotherapy (NACT). Objectives: This study aimed to evaluate the clinical characteristics and survival of patients treated with NACT followed by cytoreductive surgery and the factors affecting survival. Methods: This retrospective cohort study was conducted on 147 Advanced ovarian cancer cases who were treated with NACT referring to the Gynecology Oncology Department of Imam Khomeini Hospital in Tehran, Iran, between 2011 and 2021 and met the inclusion criteria for this study. The survival curve and Cox regression method were used to analyze the data. Results: The results revealed that 8. 9% of advanced EOC (147/1, 650) were treated with NACT and the average number of NACT courses was 4. 12 periods. The Survival rates of 1, 3, 5, and 8 years were 85. 31%, 44. 05%, 18. 35%, and 13. 77%, respectively. The mean and median of survival time were 47. 7 and 36 months, respectively. Nearly 80% of the patients had stages 3C and 4A before receiving NACT. Based on the results of the adjusted Cox regression model, tumor marker level showed a significant relationship with Survival rate (P=0. 008), and also peritoneum involvement had a clinically significant impact on survival with a hazard ratio of 2. 88. Conclusion: The results suggested that 8. 9% of ovarian cancer cases were treated with NACT. It was also revealed that the average number of NACT courses was 4. 12 periods and the 8-year Survival rate was 13. 77%. CA125 tumor marker level showed a significant relationship with Survival rate, and peritoneum involvement had a clinically significant impact on survival.

Cites

No record.

References

No record.

Cite

APA: Copy

MOUSAVI, AZAMSADAT, AKHAVAN, SETAREH, SHEIKHHASANI, SHAHRZAD, ZAMANI, NARGES, REZAYOF, ELAHE, & ESMAILZADEH, AREZOO. (2022). Clinical Characteristics and 8-year Survival Rate in Advanced Ovarian Cancer Following Neoadjuvant Chemotherapy: A Single Center Experience. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 24(10), 0-0. SID. https://sid.ir/paper/1144752/en

Vancouver: Copy

MOUSAVI AZAMSADAT, AKHAVAN SETAREH, SHEIKHHASANI SHAHRZAD, ZAMANI NARGES, REZAYOF ELAHE, ESMAILZADEH AREZOO. Clinical Characteristics and 8-year Survival Rate in Advanced Ovarian Cancer Following Neoadjuvant Chemotherapy: A Single Center Experience. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2022;24(10):0-0. Available from: https://sid.ir/paper/1144752/en

IEEE: Copy

AZAMSADAT MOUSAVI, SETAREH AKHAVAN, SHAHRZAD SHEIKHHASANI, NARGES ZAMANI, ELAHE REZAYOF, and AREZOO ESMAILZADEH, “Clinical Characteristics and 8-year Survival Rate in Advanced Ovarian Cancer Following Neoadjuvant Chemotherapy: A Single Center Experience,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 24, no. 10, pp. 0–0, 2022, [Online]. Available: https://sid.ir/paper/1144752/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops