مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Activation of β, 2-adrenergic Receptor Alleviates Collagen-induced Arthritis by Ameliorating Th17/Treg Imbalance

Pages

  16-25

Abstract

 Background: Recent research in our laboratory shows that CD4 + T cells express the β, 2 adrenergic receptor (β, 2-AR), and the sympathetic neurotransmitter norepinephrine regulates the function of T cells via β, 2-AR signaling. However, the immunoregulatory effect of β, 2-AR and its related mechanisms on rheumatoid arthritis is unknown. Objective: To explore the effects of β, 2-AR in collagen-induced arthritis (CIA) on the imbalance of T helper (Th) 17/ regulatory T (Treg) cells. Methods: In DBA1/J mice, collagen type II was injected intradermally at the tail base to prepare the CIA model. The specific β, 2-AR agonist, Terbutaline (TBL), was administered intraperitoneally beginning on day 31 and continuing until day 47 after primary vaccination, twice a day. Magnetic beads were used to sort CD3+ T cells subsets from spleen tissues. Results: In vivo, β, 2-AR agonist TBL alleviated arthritis symptoms in the CIA mice including histopathology of the ankle joints, four limbs’,arthritis score, the thickness of ankle joints, and rear paws. After TBL treatment, in the ankle joints, the levels of proinflammatory factors (IL-17/22) notably decreased and the levels of immunosuppressive factors (IL-10/TGF-β, ) significantly increased. In vitro, ROR-γ, t protein expression, Th17 cell number, mRNA expression and the releasing of IL-17/22 from CD3+ T cells reduced following TBL administration. Moreover, TBL enhanced the anti-inflammatory responses of Treg cells. Conclusion: These results suggest that β, 2-AR activation exerts anti-inflammatory effects through the amelioration of Th17/Treg imbalance in the CIA disease.

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    APA: Copy

    Lu, Jian Hua, Rui, Xiao Xiao, WANG, TINGTING, Wang, Xiaoqin, Peng, Yu Ping, & Qiu, Yi Hua. (2023). Activation of β, 2-adrenergic Receptor Alleviates Collagen-induced Arthritis by Ameliorating Th17/Treg Imbalance. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 20(1), 16-25. SID. https://sid.ir/paper/1145436/en

    Vancouver: Copy

    Lu Jian Hua, Rui Xiao Xiao, WANG TINGTING, Wang Xiaoqin, Peng Yu Ping, Qiu Yi Hua. Activation of β, 2-adrenergic Receptor Alleviates Collagen-induced Arthritis by Ameliorating Th17/Treg Imbalance. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2023;20(1):16-25. Available from: https://sid.ir/paper/1145436/en

    IEEE: Copy

    Jian Hua Lu, Xiao Xiao Rui, TINGTING WANG, Xiaoqin Wang, Yu Ping Peng, and Yi Hua Qiu, “Activation of β, 2-adrenergic Receptor Alleviates Collagen-induced Arthritis by Ameliorating Th17/Treg Imbalance,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 20, no. 1, pp. 16–25, 2023, [Online]. Available: https://sid.ir/paper/1145436/en

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