مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

13
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

7
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy

Pages

  104-113

Abstract

 Background: Abnormal humoral and cellular immune responses have been reported in immune-mediated polyneuropathies. CD137, as a costimulatory molecule and a TNF receptor Superfamily member, has been demonstrated to have a key role in the pathogenesis of many autoimmune as well as inflammatory disorders. Objective: To evaluate the transcripts levels of CD137, its ligand (CD137L), and the serum levels of soluble CD137 (sCD137) in patients with immune-mediated polyneuropathy. Methods: A total of 45 patients and 46 sex and age-matched healthy individuals were enrolled in the study. CD137 and CD137L transcript levels were assessed by the Real-Time PCR, and the serum level of sCD137 was measured using the ELISA technique. The Bayesian regression model was used for statistical analysis at the 0. 05 significance level in R 4. 1. 0 statistical environment. Results: Transcript levels of the CD137 and CD137L were higher in polyneuropathy patients in comparison with the healthy subjects (P=0. 006 for both). Conversely, the mean level of sCD137 was significantly lower in the sera of patients compared to the controls (P<0. 001). Conclusion: Our findings point to the possible role of CD137 and CD137L in immune-mediated polyneuropathy pathogenesis. More investigations are required to clarify the exact contributions of the mentioned molecules to the pathogenesis of immune-mediated polyneuropathies.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Torkestani, Shirin, ZAMANI, ALIREZA, MAZDEH, MEHRDOKHT, Talebi Ghane, Elahe, Roshanaei, Godratollah, & EFTEKHARIAN, MOHAMMAD MAHDI. (2023). Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 20(1), 104-113. SID. https://sid.ir/paper/1145445/en

    Vancouver: Copy

    Torkestani Shirin, ZAMANI ALIREZA, MAZDEH MEHRDOKHT, Talebi Ghane Elahe, Roshanaei Godratollah, EFTEKHARIAN MOHAMMAD MAHDI. Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2023;20(1):104-113. Available from: https://sid.ir/paper/1145445/en

    IEEE: Copy

    Shirin Torkestani, ALIREZA ZAMANI, MEHRDOKHT MAZDEH, Elahe Talebi Ghane, Godratollah Roshanaei, and MOHAMMAD MAHDI EFTEKHARIAN, “Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 20, no. 1, pp. 104–113, 2023, [Online]. Available: https://sid.ir/paper/1145445/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button