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Information Journal Paper

Title

The Anti-inflammatory Effect of Ginger Extract on the Animal Model of Multiple Sclerosis

Pages

  211-218

Abstract

 Background: Experimental Autoimmune Encephalomyelitis (EAE), as an autoimmune disease in the central nervous system (CNS), is an animal model for Multiple Sclerosis (MS) mediated by T lymphocytes. Objective: To investigate Ginger extract’, s effect on reducing inflammation and improving the symptoms in the EAE model. Methods: The EAE was induced by injecting MOG35-55 and pertussis toxin into eight-week-old female C57BL6 mice. The mice were treated with an intraperitoneal injection of 300 mg/kg/ day of hydroalcoholic extract of Ginger for 21 days. The disease severity and weight changes were measured daily. Then, the mice spleens were removed,the gene expressions of interleukin (IL)-17, transforming growth factor beta (TGF-β, ), interferon-γ,(IFN-γ, ), and tumor necrosis factor α,(TNF-α, ) were analyzed by Real-time PCR and the percentage of regulatory T lymphocytes (Treg cells) was determined by flow cytometry. Serum nitric oxide and antioxidant capacity were measured, and brain tissue sections were prepared to investigate the leukocyte infiltration and plaque formation. Results: The severity of symptoms in the intervention group was lower than in the control. The gene expression levels of inflammatory Cytokines, including IL-17 (P=0. 04) and IFN-γ,(P=0. 01), were reduced. The Treg cells increased significantly, and the serum nitric oxide level was lower in the Ginger-treated group. There was no significant difference in lymphocyte infiltration in the brain between the two groups. Conclusion: The present study indicated that Ginger extract could effectively reduce the inflammatory mediators and modulate immune responses in EAE.

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    APA: Copy

    Kamankesh, Fatemeh, GANJI, ALI, GHAZAVI, ALI, & MOSAYEBI, GHASEM. (2023). The Anti-inflammatory Effect of Ginger Extract on the Animal Model of Multiple Sclerosis. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 20(2), 211-218. SID. https://sid.ir/paper/1145605/en

    Vancouver: Copy

    Kamankesh Fatemeh, GANJI ALI, GHAZAVI ALI, MOSAYEBI GHASEM. The Anti-inflammatory Effect of Ginger Extract on the Animal Model of Multiple Sclerosis. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2023;20(2):211-218. Available from: https://sid.ir/paper/1145605/en

    IEEE: Copy

    Fatemeh Kamankesh, ALI GANJI, ALI GHAZAVI, and GHASEM MOSAYEBI, “The Anti-inflammatory Effect of Ginger Extract on the Animal Model of Multiple Sclerosis,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 20, no. 2, pp. 211–218, 2023, [Online]. Available: https://sid.ir/paper/1145605/en

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