Effects of Blocking NLRP3 Inflammasome on Type II Innate Lymphoid Cell Response in Allergic Rhinitis

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Gong Guoqing; Huang Peng; Yang Changliang; Huang Chengcheng; Zhang Zhao; Chen Ruiyao; Sun Tingfeng; YANG Guang

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Journal Paper

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Journal: Iranian Journal of Immunology Year:2023 | Volume:20 | Issue:3 Page(s): 287-302

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Title

Effects of Blocking NLRP3 Inflammasome on Type II Innate Lymphoid Cell Response in Allergic Rhinitis

Author(s)

Keywords

Allergic Rhinitis

MCC950

NLRP3 Inflammasome

Type II Innate Lymphoid Cell

Abstract

Background: Type 2 innate lymphoid cells (ILC2s) and NLRP3 Inflammasome are related to allergic and inflammatory responses. NLRP3 Inflammasome inhibitor MCC950 was demonstrated to ameliorate Allergic Rhinitis (AR) in animal models. Objective: To elucidate the effect of MCC950 on ILC2 responses in AR. Methods: N L R P 3 i n fl a m m a s o m e, I L C 2 s, I L-5+ ILC2s, IL-13 + ILC2s, and Th2-related factors were examined in 30 AR patients. ILC2s were identified as Lin-CRTH2 + CD127 + lymphocytes. ILC2s isolated from PBMCs were stimulated with LPS plus ATP. The effect of MCC950, IL-1β, , and IL-18 on ILC2 responses was detected by flow cytometry. AR models were established in 60 BALB/c mice. Nasal symptoms and ILC2 responses in the AR models after MCC950 treatment were detected. Human nasal epithelial cells were stimulated with IL-13 (10 ng/mL) and treated with MCC950 (10 μ, M). Results: AR patients showed activated NLRP3 Inflammasome and increased ILC2 responses compared to controls. NLRP3 Inflammasome levels in the AR patients were positively related to the proportion of ILC2s, IL-5+ILC2s, and IL-13 + ILC2s in total PBMCs. MCC950 treatment or IL-1β, /IL-18 suppression inhibited ILC2 proliferation and Th2-related factors (GATA3, RORα, , IL-5, and IL-13). MCC950 administration alleviated frequencies of nasal rubbing and sneezes in the AR models. ILC2s, IL-5 + ILC2s, and IL-13 + ILC2s in mice were reduced by MCC950. MCC950 inhibited NLRP3 Inflammasome in the in vitro models of AR. Conclusion: MCC950 inhibited ILC2 responses in AR and mice models, suggesting that blocking NLRP3 Inflammasome may be a promising target for AR clinical treatment.

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APA: Copy

Gong, Guoqing, Huang, Peng, Yang, Changliang, Huang, Chengcheng, Zhang, Zhao, Chen, Ruiyao, Sun, Tingfeng, & YANG, Guang. (2023). Effects of Blocking NLRP3 Inflammasome on Type II Innate Lymphoid Cell Response in Allergic Rhinitis. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 20(3), 287-302. SID. https://sid.ir/paper/1145612/en

Vancouver: Copy

Gong Guoqing, Huang Peng, Yang Changliang, Huang Chengcheng, Zhang Zhao, Chen Ruiyao, Sun Tingfeng, YANG Guang. Effects of Blocking NLRP3 Inflammasome on Type II Innate Lymphoid Cell Response in Allergic Rhinitis. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2023;20(3):287-302. Available from: https://sid.ir/paper/1145612/en

IEEE: Copy

Guoqing Gong, Peng Huang, Changliang Yang, Chengcheng Huang, Zhao Zhang, Ruiyao Chen, Tingfeng Sun, and Guang YANG, “Effects of Blocking NLRP3 Inflammasome on Type II Innate Lymphoid Cell Response in Allergic Rhinitis,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 20, no. 3, pp. 287–302, 2023, [Online]. Available: https://sid.ir/paper/1145612/en

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