مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

14
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

8
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response

Pages

  316-326

Abstract

 Background: Lupus Nephritis (LN) refers to the injury caused by Systemic Lupus Erythematosus (SLE) involving the kidneys. A previous study identified angiopoietin-like protein 4 (ANGPTL4) as a novel urinary biomarker for tracking disease activity in LN. Objective: To investigate the detailed role and regulatory mechanism of ANGPTL4 in experimental models of LN. Methods: MRL/lpr mice 11-week-old were injected with adenoassociated virus (AAV)-mediated ANGPTL4 short hairpin RNA (shRNA). At 16 and 20 weeks of age, 24-h urine samples were harvested to measure proteinuria levels. After the mice were sacrificed, blood and kidney tissues were harvested to examine serum creatinine (cr) and blood urea nitrogen (BUN) levels, kidney histological changes, and pro-inflammatory cytokine production. Additionally, the levels of NLRP3 Inflammasome-associated molecules in mouse renal tissues were detected to clarify the underlying mechanism. Results: The AAV-sh-ANGPTL4 injection significantly reduced the proteinuria, cr, and BUN levels in MRL/lpr mice. ANGPTL4 silencing ameliorated glomerular, tubular, and interstitial damage in mice, mitigating the pathological alternations of LN. In addition, ANGPTL4 knockdown repressed pro-inflammatory cytokine production in the kidneys. Mechanically, ANGPTL4 suppression inhibited NLRP3 Inflammasome expression in renal tissues of mice. Conclusion: ANGPTL4 silencing inhibits the NLRP3 Inflammasome-mediated inflammatory response, thereby ameliorating LN in MRL/lpr mice.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Luo, Dan, LI, JUN, Hu, Manli, Wang, You, Pi, Pei, Ning, Min, & WU, JUN. (2023). Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 20(3), 316-326. SID. https://sid.ir/paper/1145614/en

    Vancouver: Copy

    Luo Dan, LI JUN, Hu Manli, Wang You, Pi Pei, Ning Min, WU JUN. Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2023;20(3):316-326. Available from: https://sid.ir/paper/1145614/en

    IEEE: Copy

    Dan Luo, JUN LI, Manli Hu, You Wang, Pei Pi, Min Ning, and JUN WU, “Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 20, no. 3, pp. 316–326, 2023, [Online]. Available: https://sid.ir/paper/1145614/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button