Increased Serum Levels of IL-1β,after Ischemic Stroke are Inversely Associated with Vitamin D

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BAYAT MAHNAZ; Razavi Moosavi Niloufar; Karimi Najmeh; Rahimi Moosa; BORHANI HAGHIGHI AFSHIN

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Journal: Iranian Journal of Immunology Year:2023 | Volume:20 | Issue:3 Page(s): 359-367

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Title

Increased Serum Levels of IL-1β,after Ischemic Stroke are Inversely Associated with Vitamin D

Author(s)

Keywords

Inflammation

Interleukin-1β

Ischemic Stroke

Vitamin D

Abstract

Background: The initial inflammatory reaction starts following occlusion in Ischemic Stroke (IS). Interleukin-1β,(IL-1β, ) is a proinflammatory cytokine with a crucial role in the pathogenesis of neurodegenerative disorders. Objective: To investigate the levels of IL-1β,and Vitamin D (VitD) in patients with IS compared with controls and their correlation. Methods: The serum level of 25-OH VitD and IL-1β,was assessed in 102 IS patients (0-24 h after stroke) and 102 controls with an enzyme-linked immunosorbent assay (ELISA) kit. Results: We found a significant increase in IL-1β,(80. 14±, 6. 8 vs. 60. 32±, 4. 1 pg/ml, p<0. 05) and a decrease in VitD level (24. 3±, 1. 4 vs. 29. 9±, 1. 5 ng/ml, p<0. 01) in the IS patients compared with the controls. There was a significantly positive correlation between the National Institutes of Health Stroke Scale (NIHSS) and IL-1β,according to both the Spearman correlation (r=0. 35, p=0. 0003) and the linear regression (beta=0. 255, p=0. 014). Also, a significant negative association between VitD and NIHSS was detected by the Spearman correlation (r=-0. 41, p<0. 0001) and the linear regression (beta=-0. 381, p=0. 000). Moreover, we found a significant negative correlation (r=-0. 26, p=0. 006) between the serum levels of VitD and IL-1β,in the patient group. Conclusion: Ischemic Stroke correlates positively with IL-1β,and negatively with VitD levels. The speculated role of VitD deficiency in the evolution and severity of stroke may be justified by its role in the modification of Inflammation.

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APA: Copy

BAYAT, MAHNAZ, Razavi Moosavi, Niloufar, Karimi, Najmeh, Rahimi, Moosa, & BORHANI HAGHIGHI, AFSHIN. (2023). Increased Serum Levels of IL-1β,after Ischemic Stroke are Inversely Associated with Vitamin D. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 20(3), 359-367. SID. https://sid.ir/paper/1145618/en

Vancouver: Copy

BAYAT MAHNAZ, Razavi Moosavi Niloufar, Karimi Najmeh, Rahimi Moosa, BORHANI HAGHIGHI AFSHIN. Increased Serum Levels of IL-1β,after Ischemic Stroke are Inversely Associated with Vitamin D. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2023;20(3):359-367. Available from: https://sid.ir/paper/1145618/en

IEEE: Copy

MAHNAZ BAYAT, Niloufar Razavi Moosavi, Najmeh Karimi, Moosa Rahimi, and AFSHIN BORHANI HAGHIGHI, “Increased Serum Levels of IL-1β,after Ischemic Stroke are Inversely Associated with Vitamin D,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 20, no. 3, pp. 359–367, 2023, [Online]. Available: https://sid.ir/paper/1145618/en

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