The effect of tranexamic acid drug on hemodynamic changes in patients undergoing septorhinoplasty surgery: A double-blind randomized clinical trial study

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Sohrabpour Mojtaba; Sanie Jahromi Mohammad Sadegh

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Journal Paper

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Journal: Pars Journal of Medical Sciences Year:2023 | Volume:21 | Issue:4 Page(s): 1-9

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Title

The effect of tranexamic acid drug on hemodynamic changes in patients undergoing septorhinoplasty surgery: A double-blind randomized clinical trial study

Author(s)

Sohrabpour Mojtaba | Sanie Jahromi Mohammad Sadegh | Issue Writer Certificate

Keywords

Tranexamic AcidQ4

Hemodynamic ChangesQ4

SeptorhinoplastyQ4

Abstract

Introduction: Rhinoplasty is one of the most challenging cosmetic surgeries. The nature of surgery itself and hemodynamic instability in patients causes bleeding during surgery, which affects the quality of the surgical field of view, complications during and after surgery, and the outcome of surgery. Therefore, the purpose of this study is the effect of Tranexamic Acid drug on Hemodynamic Changes in patients undergoing Septorhinoplasty surgery.Materials & Methods: This double-blind randomized clinical trial study was conducted on 51 patients aged 18 to 44 years with anesthesia class І, II who were candidates for Septorhinoplasty surgery. The patients were randomly divided into two groups of Tranexamic Acid and control. Hemodynamic parameters at times; before induction, after induction, 1 minute after induction, 5 minutes after induction, 30, 60, 90 and 120 minutes during the operation, entry into recovery and exit from recovery were measured. Data analysis was done using spss software version 21 and descriptive statistics (mean and standard deviation) and inferential statistical tests.Results: The average trend of systolic and diastolic blood pressure from the time before induction to outside of recovery in the control and tranramic acid groups showed a significant difference (P<0.001). In the times before and after induction, 5 minutes, 15 minutes, 30 minutes, 60 minutes, 90 minutes, 120 minutes, a significant difference in the average heart rate between the two groups was observed (P<0.05). In the control group and the tranamic acid group, the mean trend of O2SAT from the time before induction to the time outside of recovery showed a significant difference (P<0.001).Conclusion: The results of the present study showed that the use of a dose of 250 mg of Tranexamic Acid had adecreasing trend in the average Hemodynamic Changes over time, and during these times, the decreasing changes in heart rate were significant. Therefore, it seems that Tranexamic Acid can be used in Septorhinoplasty surgery to maintain hemodynamic stability.

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