Effect of Aerobic Training and Vitamin D3 Supplementation and Their Interaction on Pancreatic Islet Morphology and Insulin Resistance Index in Male Type 2 Diabetic Rats Induced by High-Fat Diet/ Streptozotocin

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Salavati Rashad; Rahman Rahimi Mohammad; Ahmadi Slahadin; Ghaeeni Saeed

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Research in Medicine Year:2024 | Volume:48 | Issue:1 Page(s): 38-49

Download Full-Text

Persian Verion

View:

Download:

Cites:

Information Journal Paper

Title

Effect of Aerobic Training and Vitamin D3 Supplementation and Their Interaction on Pancreatic Islet Morphology and Insulin Resistance Index in Male Type 2 Diabetic Rats Induced by High-Fat Diet/ Streptozotocin

Author(s)

Salavati Rashad | Rahman Rahimi Mohammad | Ahmadi Slahadin | Ghaeeni Saeed | Issue Writer Certificate

Keywords

ype 2 diabetesQ4

pancreatic isletsQ4

aerobic exercisesQ4

vitamin D3Q4

insulin resistanceQ4

Abstract

Background and Aim: The dysfunction of pancreatic islets plays a crucial role in the development of diabetes. Considering the positive effects of aerobic training and the protective role of vitamin D3 in reducing metabolic disorders, including diabetes, this study aimed to investigate the impact of aerobic training and vitamin D3 supplementation and their interactions on pancreatic islet morphology and insulin resistance index in type 2 diabetes rat model induced by high-fat diet (HFD) and low-dose streptozotocin (STZ). Methods: In this experimental study, 40 male Wistar rats were randomly assigned to non-diabetic included in this experiment. Eight rats were assigned to the normal control group (C) and fed a standard diet. To induce type 2 diabetes, the remaining rats (n = 32) were fed a HFD for 6 weeks, followed by a single intraperitoneal (i. p. ) injection of streptozotocin (STZ) at a dose of 40 mg per kilogram of body weight. Diabetic rats were divided into four equal groups: diabetic (DC), aerobic training (DE), vitamin D3 supplementation (DD3), and aerobic training combined with vitamin D3 supplementation (DD3E). Aerobic training consisted of treadmill running five times a week. vitamin D3 supplementation involved a weekly i. p. injection of 10, 000 units. Plasma insulin and fasting glucose levels were measured. Statistical analyses were performed using One-way ANOVA followed by Bonferroni's post-hoc comparisons tests. Values are reported as mean ± SD and the level of significance has been considered at (p < 0. 05). Results: Type 2 diabetes resulted in a reduction in the number and size of pancreatic islets. Both aerobic training and vitamin D3 supplementation increased the level and number of pancreatic islets, compared with the diabetic group (8. 48 ± 0. 16) insulin resistance in all three groups of DE (3. 99 ± 0. 51), DD3 (5. 15 ± 0. 32) and DD3E (3. 80 ± 0. 30) showed a significant reduction (p˂0. 0001). Additionally, in the intervention group DD3E, the fasting plasma insulin (0. 25 ± 0. 03) and glucose (277 ± 26. 58) levels were significantly lower compared to the DC group (p ˂ 0. 0001). Conclusion: It seems that based on the results of this study, aerobic training and vitamin D3 supplementation, as well as Their Interaction, led to a reduction in insulin resistance index and an increase in the size and number of pancreatic islets in type 2 diabetic rats induced by high-fat diet and streptozotocin.

Cites

No record.

References