The Antioxidant Effect of Apigenin on Human Sperm Quality after Freezing-Thawing

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Esmaeili Irani Asieh; Nikoozar Bahare; Arbabian Maryam; Tavalaee Marziyeh; Nasr Esfahani Mohammad Hossein

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Journal Paper

Paper Information

Journal: Journal of Gorgan University of Medical Sciences Year:2024 | Volume:26 | Issue:1 Page(s): 77-86

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Information Journal Paper

Title

The Antioxidant Effect of Apigenin on Human Sperm Quality after Freezing-Thawing

Author(s)

Keywords

Oxidative Stress [MeSH]Q4

Antioxidants [MeSH]Q4

Apigenin [MeSH]Q4

Spermatozoa [MeSH]Q4

Freeze-ThawQ4

Abstract

Background and Objective: Antioxidant apigenin (AP) is a natural, non-mutagenic, and less toxic flavonoid with pharmacological anti-cancer, anti-viral, anti-bacterial, anti-apoptotic, and anti-inflammatory activities. This antioxidant is easily received by the cell, binds to sperm DNA, and forms a DNA-AP complex, thereby protecting sperm DNA. The present study was conducted to determine the antioxidant effect of AP on human sperm quality after freezing-thawing. Methods: In this descriptive-analytical study, 10 normozoospermic samples underwent freezing-thawing conditions, and sperm functional tests were investigated in different AP concentrations, including 0. 4 mM, 0. 2 mM, 0. 1 mM, and 0. 05 mM. Results: The quality of total sperm parameters and functional tests decreased after freezing compared to before freezing. Among the AP concentrations, only in the 0. 2 mM AP concentration, the improvement of the additional histone percentage, protamine deficiency, and sperm DNA health were observed compared to the control,this finding was not statistically significant. Conclusion: The use of AP with a concentration of 0. 2 mM during freezing-thawing culminates in improving sperm functional tests.

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