Evaluating the importance of HER2 biomarker performance in diagnosing and relating it to other clinical factors in women with breast cancer referring to the Besat Clinic

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Karimian Paridokht; Shams Shima; Rahbar Taramsari Morteza; Mirpour Hassan Kiadeh Seyed Hossein; Norollahi Seyedeh Elham; Babaei Kosar; Davoudi kiakalayeh Ali; Samadani Ali Akbar

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2023 | Volume:25 | Issue:3 Page(s): 299-308

Download Full-Text

Persian Verion

View:

Download:

Cites:

Information Journal Paper

Title

Evaluating the importance of HER2 biomarker performance in diagnosing and relating it to other clinical factors in women with breast cancer referring to the Besat Clinic

Author(s)

Keywords

Breast CancerQ4

Tumor BiomarkersQ4

HER-2Q4

Abstract

2Introduction: Breast Cancer is one of the most common cancers in women and the second leading cause of death from cancer in women aged 20-59. Correspondingly, tumor markers such as HER-2/neu and PR ER P53 can be used to determine the severity of the disease and how to treat these patients. The purpose of this study was to investigate the importance of HER-2 biomarker function in diagnosis and its relationship with other clinical factors in women with Breast Cancer. Materials and Methods: This cross-sectional-analytical study included all Breast Cancer patients who were referred to Rasht's Besat Clinic between 2018 and 2019, and their Breast Cancer was confirmed by pathology results. The CVR coefficient was obtained for each question (-0.8 to 1) and the CVI index was above 80%. HER-2 biomarker status was recorded in immunohistochemical evaluation. Results: In this study, there is also a significant relationship between HER-2 biomarkers with the age of diagnosis, place of residence, marital status, education, exercise frequency, menstrual cycle, age at first menstruation, age at first live birth, history of abortion, history of Breastfeeding, history of the contraceptive hormone, history of smoking, alcohol, drugs, history of Breast Cancer and non-Breast Cancer in first and second degree relatives, history of HPV, history of metastasis was not found. A significant correlation was found between HER-2 biomarker and weight, age of first pregnancy, and the number of children. Conclusion: Based on the results of this study, the expression of HER-2 biomarkers in Breast Cancer patients increases with increasing weight, increasing the age of patients, and decreasing the number of children.

Cites

No record.

References