An Overview of molecular basis of Alzheimer's Disease from the Perspective of Molecular Medicine

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Shoja pour Mana; asghar zade samira

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Journal Paper

Paper Information

Journal: Journal of Arak University Medical Sciences Year:2023 | Volume:26 | Issue:4 Page(s): 14-20

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Information Journal Paper

Title

An Overview of molecular basis of Alzheimer's Disease from the Perspective of Molecular Medicine

Author(s)

Shoja pour Mana | asghar zade samira | Issue Writer Certificate

Keywords

Alzheimer's diseaseQ4

biomarkersQ4

molecular medicineQ4

molecular basisQ4

Abstract

2Background and Aim: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by loss of memory and multiple cognitive impairments. Materials and Methods: In this study, key terms were searched in reputable Persian and English databases including DOAJ, PubMed, Google Scholar, LISTA (EBSCO), Embase, and Web of Science. Articles focusing on the molecular basis and pathogenesis of the disease, as well as biomarkers for Alzheimer's diagnosis, were reviewed. In this article, we have attempted a comprehensive review not only of the molecular basis of Alzheimer's disease from a molecular medical perspective but also to address numerous molecular diagnostic methods and biomarkers at both clinical and research levels in this disease. Ethical Considerations: All Ethical principles in writing this article have principles been observed according to the instructions of National Ethics Committee and the COPE regulations Findings: The results of this review study indicate that the major factors involved in the pathogenesis of Alzheimer's include beta-amyloid peptides, hyperphosphorylation of tau protein, and activation of inflammatory and oxidative stress pathways. Subsequently, this leads to synaptic loss, mitochondrial dysfunction, and proliferation of activated astrocytes and microglia, which are clinically manifested as memory loss in patients." Conclusion: Although no precise diagnostic method exists for AD, current clinical recommendations for AD diagnosis include assessing tau protein and beta-amyloid (Aβ) peptides in cerebrospinal fluid, magnetic resonance imaging (MRI) for brain volume, and positron emission tomography (PET) scanning for Aβ plaques and/or glucose metabolism in the brain.

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