Investigating the therapeutic effect of p-cymene on oxidative stress and mRNA level of mTOR gene in diabetic rats

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Arabloei Sani Maryam; Hajebrahimi Zahra; Yaghmaei Parichehreh; Hayati Roodbari Nasim

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Journal Paper

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Journal: Journal of Arak University Medical Sciences Year:2023 | Volume:26 | Issue:5 Page(s): 20-26

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Title

Investigating the therapeutic effect of p-cymene on oxidative stress and mRNA level of mTOR gene in diabetic rats

Author(s)

Arabloei Sani Maryam | Hajebrahimi Zahra | Yaghmaei Parichehreh | Hayati Roodbari Nasim | Issue Writer Certificate

Keywords

DiabetesQ4

p-cymeneQ4

catalaseQ4

glutathione peroxidaseQ4

mTORQ4

Abstract

2Background and Aim: Diabetes is a type of metabolic disease and one of the most common endocrine diseases. Oxidative stress and inflammation play an important role in the development and progression of Diabetes. mTOR signaling pathway play an important role in glucose homeostasis and proliferation of pancreatic beta cells. In the present study, the therapeutic effects of p-cymene on oxidative stress markers and expression of the mTOR gene in diabetic male Wistar rats were investigated. Materials and Methods: Diabetes was induced by injecting 55 mg/kg body weight of streptozotocin. Biochemical analyses of pancreatic tissue and real-time PCR were done to investigate the effects of metformin (55 mg/kg body weight) and p-cymene (25, 50, and 100 mg/kg body weight) on the activities of catalase and glutathione peroxidase enzymes and mTOR gene expression. Findings: Streptozotocin decreased catalase and glutathione peroxidase enzymes and decreased the expression of the mTOR gene in pancreatic tissue. Treatment with metformin or p-cymene improved the activities of catalase and glutathione peroxidase enzymes and the expression of the mTOR gene in a dose-independent manner. Conclusion: Results indicate that p-cymene has antioxidant properties and can regulate the mTOR signaling pathway. Therefore, p-cymene may be effective for the treatment of Diabetes alone or in combination with metformin.

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