Effects of silymarin on hexaflumuron-induced lesions in rat kidneys

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Ghasempour Amirmohammad; Hoseini Seyed Mohammad

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Feyz Medical Sciences Journal Year:2024 | Volume:28 | Issue:1 Page(s): 17-24

Download Full-Text

Persian Verion

View:

Download:

Cites:

Information Journal Paper

Title

Effects of silymarin on hexaflumuron-induced lesions in rat kidneys

Author(s)

Ghasempour Amirmohammad | Hoseini Seyed Mohammad | Issue Writer Certificate

Keywords

HexaflumuronQ4

SilymarinQ4

kidneyQ4

RatQ4

AntioxidantQ4

Abstract

2Background and Aim: Hexaflumuron, a benzoylphenylurea insecticide, has nephrotoxic effects in mammals. The use of plant Antioxidants to improve and prevent poisoning with insecticides has gained popularity. This study aims to evaluate the effects of Silymarin, an herbal Antioxidant, in ameliorating the lesions caused by Hexaflumuron in Rat kidneys. Methods: In this experimental study, 40 Rats were randomly divided into five groups (n=8): a control group, a group receiving Silymarin (200 mg/kg), treatment group 1 (Hexaflumuron at 22 mg/kg and Silymarin at 100 mg/kg), treatment group 2 (Hexaflumuron at 22 mg/kg and Silymarin at 200 mg/kg), and a group receiving Hexaflumuron (at 22 mg/kg). The gavage lasted for 28 days. After the gavage period, the blood sample was collected from the Rats, and kidney tissue samples were obtained post-euthanasia. Histopathological examination was qualitatively conducted to assess lesion presence. Results: Silymarin significantly reduced the elevated concentrations of serum urea and creatinine induced by Hexaflumuron (P<0.05). The use of Silymarin largely mitigated vacuolar degeneration and hyperemia caused by Hexaflumuron in the kidneys. Conclusion: Based on the findings, it can be inferred that Silymarin at a dose of 200 mg/kg, as an herbal Antioxidant, effectively prevents the adverse changes induced by Hexaflumuron in the kidneys.

Cites

No record.

References