The effect of interval training and omega-3 on endoplasmic reticulum stress in the liver tissue of nonalcoholic fatty liver disease (NAFLD) rats

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Kazemi Mostafa; Abdi Ahmad; Barari Alireaz; Mehrabani Javad

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Journal Paper

Paper Information

Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2024 | Volume:34 | Issue:1 Page(s): 25-36

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Title

The effect of interval training and omega-3 on endoplasmic reticulum stress in the liver tissue of nonalcoholic fatty liver disease (NAFLD) rats

Author(s)

Kazemi Mostafa | Abdi Ahmad | Barari Alireaz | Mehrabani Javad | Issue Writer Certificate

Keywords

ExerciseQ4

Omega-3Q4

GRP78Q4

CHOPQ4

Nonalcoholic fatty liver diseaseQ4

Abstract

Background: Endoplasmic reticulum stress (ERS) plays an important role in the development of non-alcoholic fatty liver disease (NAFLD). In this study, the effect of Omega-3 consumption and interval Exercise alone or in combination on ERS in rats with NAFLD was investigated. Materials and methods: In this experimental study, 40 male Wistar rats (mean weight 156. 98±7. 82) were divided into 5 groups: Control-Normal (CN), NAFLD, NAFLD-Training (TRNAF), NAFLD-Supplement (SUPNAF) and NAFLD-Training-Supplement (TRSUPNAF). The supplement groups received 1 g of Omega3 (per kg of body weight) orally during the intervention period. Interval training program including running on treadmill with a speed of 14-28 meters per minute, was performed 5 days a week for eight weeks. Results: Induction of NAFLD increased GRP78, CHOP, ALT and AST (p=0. 0001). The expression of GRP78 and CHOP was significantly decreased in TRNAF (p=0. 0001 and p=0. 001 respectively) and SUPNAF (p=0. 0001 and p=0. 001 respectively) groups compared to NAFLD. ALT and AST also significantly decreased in TRNAF (p=0. 0001 and p=0. 0001) and SUPNAF (p=0. 0001 and p=0. 001 respectively) groups. The combined intervention of interval training with Omega-3 supplement was not significant compared to the effect of each intervention alone on GRP78, CHOP, ALT and AST (p<0. 05). Conclusion: Interval training and Omega-3 consumption inhibited ER stress in liver tissue through reduction in GRP78 and CHOP expression. However, the simultaneous effect of interval training and Omega-3 on ERS needs more research.

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