New Delhi metallo-beta-lactamase-producing Enterobacteriaceae isolated from urine sample in Karaj

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Neysari Tabrizi Sogol; Haddadi Azam; Babapour Ebrahim

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Journal Paper

Paper Information

Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2024 | Volume:34 | Issue:2 Page(s): 163-169

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Information Journal Paper

Title

New Delhi metallo-beta-lactamase-producing Enterobacteriaceae isolated from urine sample in Karaj

Author(s)

Neysari Tabrizi Sogol | Haddadi Azam | Babapour Ebrahim | Issue Writer Certificate

Keywords

Urinary tract infectionQ4

Antibiotic resistanceQ4

NMD-1Q4

PCR.Q4

Abstract

Background: Urinary tract infection is one of the most important infectious diseases. Beta-lactam antibiotics, especially the third and fourth generations of cephalosporins, are effective in treating this infection. The production of beta-lactamase enzyme by bacteria is the most important mechanism of resistance to various beta-lactam antibiotics, which poses a serious threat to the use of these drugs in the future. The aim of this study is to investigate the presence of new beta-lactamases in Enterobacteriaceae isolated from Urinary tract infections. Materials and methods: In this cross-sectional descriptive research, 100 isolates of Enterobacteriaceae were isolated from urine samples collected from the hospitals and laboratories of Alborz province. The isolates were identified by standard biochemical and microbial tests. The pattern of Antibiotic resistance of the isolates to 11 different antibiotics was investigated by the Kirby Bauer method. The isolates were analyzed phenotypically in terms of β-lactamase production (NDM-1). In the case of isolates with β-lactamase blaNDM-1, PCR.was done with the help of specific primers, and finally the PCR.product was sequenced and analyzed. Results: The pattern of Antibiotic resistance was observed as follows: ampicillin (85%), imipenem (70%), kanamycin (66%), cefotaxime (51%), ceftriaxone (51%), tetracycline (50%), ceftazidime (% 49), ciprofloxacin (46%), neurofloxacin (36%), gentamicin (29%), meropenem (27%). The results of PCR.showed that 2% of the isolates had blaNDM-1 gene. Conclusion: The increase of Antibiotic resistance in clinical isolates and the emergence of new beta-lactamases warn that the policy of using antibiotics to treat bacterial infections should be changed.

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