Effect of saffron supplementation and endurance training on the concentration of interleukin-8, C-reactive protein, and clinical symptoms in outpatients with COVID-19

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Halalkhor Fateme; Pourrahim Korkchi Amina; Siahkouhian Marefat

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Journal Paper

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Journal: Yafteh Year:2023 | Volume: | Issue: Page(s): 50-64

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Information Journal Paper

Title

Effect of saffron supplementation and endurance training on the concentration of interleukin-8, C-reactive protein, and clinical symptoms in outpatients with COVID-19

Author(s)

Halalkhor Fateme | Pourrahim Korkchi Amina | Siahkouhian Marefat | Issue Writer Certificate

Keywords

Covid-19Q4

C-reactive proteinQ4

ExerciseQ4

Interleukin-8Q4

SaffronQ4

Abstract

2Background: Covid-19 is considered a new disease across the globe. Physical activity reduces risk factors, and with anti-inflammatory and antioxidant properties, Saffron is used as a traditional herbal medicine to treat cough and asthma. Therefore, the present study aimed to assess the effect of Saffron supplementation and endurance training on the concentration of C-reactive protein, Interleukin-8, and clinical symptoms in outpatients with Covid-19. Materials and Methods: The present research was conducted based on a randomized, double-blind, four-group, pretest-posttest design. The statistical population of this research entailed all outpatients with Covid-19 referred to the health center of Keshkosrai. Among this population, 36 cases were randomly selected. The research hypotheses were evaluated using SPSS software at a significance level of P<0. 05 using the statistical test of analysis of covariance (ANCOVA) and paired T-test. Results: The results of ANCOVA demonstrated that after adjusting the effect of baseline values, height, and body mass index, there was a statistically significant difference between the groups in terms of the mean change of Interleukin-8, C-reactive protein, partial oxygen pressure (SpO2), and body temperature (P<0. 05). That is, the type of intervention can markedly affect the change of Interleukin-8, C-reactive protein, partial oxygen pressure, and body temperature. Conclusion: As evidenced by the obtained results, it is possible to use Saffron as an auxiliary therapeutic method, as well as regular sports activity, which helps to control pathogens, including Covid-19, by boosting the body's immunity.

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