THE PREVALENCE OF COMMON MUTATION FREQUENCY IN K-RAS CODONS 12, 13 IN IRANIAN COLORECTAL CANCER PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SOBHANI SANAZ; GHAFFARPOUR MASOUD; MOSTAKHDEMIN HOSSEINI ZAHRA; KAMALI FATEMEH; NOUR MOHAMMADI ZAHRA; HOUSHMAND MASOUD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: GENETICS IN THE 3RD MILLENNIUM Year:2010 | Volume:8 | Issue:2 Page(s): 2011-2018

Download Full-Text

Persian Verion

View:

1,432

Download:

Cites:

Information Journal Paper

Title

THE PREVALENCE OF COMMON MUTATION FREQUENCY IN K-RAS CODONS 12, 13 IN IRANIAN COLORECTAL CANCER PATIENTS

Author(s)

Keywords

K-RASQ3

MUTATIONQ3

COLON CANCERQ2

Abstract

Colorectal cancer (CRC) is the most gastrointestinal cancer in United States and Europe. It is the third most common cancer in Iranian men, and fourth in Iranian women. Codons 12 and 13 are the hot spots for MUTATIONs in colorectal cancer patients, which encodes the activated RAS protein. According to recent researches, somatic MUTATIONs in codons 12, 13 (exon1) of K-RAS gene are discovered in 20% - 50% human CRCs. The aim of this study was to estimate the contribution of K-RAS gene MUTATIONs in codons 12, 13 in the incidence, and its association with clinicopathologic information like age, sex, familial history, site of primary and histology in Iranian colorectal cancer patients. In this study, we have analyzed 59 tissue specimens of colorectal cancer patients using PCR/sequencing method for codons 12, 13 of K-RAS gene.20.3% of patients (10 in codon 12 and 2 in codon 13) have shown a point MUTATION. About 60% of MUTATIONs occur in rectum and 41.7% in colon. More than 80% of MUTATIONs were in adenocarcinomas and less MUTATIONs in mucinous. Most MUTATIONs were found over the age of 60. Only two patients (16.6%) had a familial history for cancer. According to low rates of K-RAS MUTATIONs in codons 12, 13, we can say they are not common in Iranian patients. The MUTATION pattern for Iranian patients differs from other nationalities. Perhaps we can find point MUTATIONs in other exons, and we suggest whole genome sequencing for our patients.

Cites

No record.

References

No record.

Cite

APA: Copy

SOBHANI, SANAZ, GHAFFARPOUR, MASOUD, MOSTAKHDEMIN HOSSEINI, ZAHRA, KAMALI, FATEMEH, NOUR MOHAMMADI, ZAHRA, & HOUSHMAND, MASOUD. (2010). THE PREVALENCE OF COMMON MUTATION FREQUENCY IN K-RAS CODONS 12, 13 IN IRANIAN COLORECTAL CANCER PATIENTS. GENETICS IN THE 3RD MILLENNIUM, 8(2), 2011-2018. SID. https://sid.ir/paper/117177/en

Vancouver: Copy

SOBHANI SANAZ, GHAFFARPOUR MASOUD, MOSTAKHDEMIN HOSSEINI ZAHRA, KAMALI FATEMEH, NOUR MOHAMMADI ZAHRA, HOUSHMAND MASOUD. THE PREVALENCE OF COMMON MUTATION FREQUENCY IN K-RAS CODONS 12, 13 IN IRANIAN COLORECTAL CANCER PATIENTS. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2010;8(2):2011-2018. Available from: https://sid.ir/paper/117177/en

IEEE: Copy

SANAZ SOBHANI, MASOUD GHAFFARPOUR, ZAHRA MOSTAKHDEMIN HOSSEINI, FATEMEH KAMALI, ZAHRA NOUR MOHAMMADI, and MASOUD HOUSHMAND, “THE PREVALENCE OF COMMON MUTATION FREQUENCY IN K-RAS CODONS 12, 13 IN IRANIAN COLORECTAL CANCER PATIENTS,” GENETICS IN THE 3RD MILLENNIUM, vol. 8, no. 2, pp. 2011–2018, 2010, [Online]. Available: https://sid.ir/paper/117177/en

Related Journal Papers