HLA PROFILE AND CLINICAL PRESENTATION OF MULTIPLE SCLEROSIS IN IRAN

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KALANIE HOSSEIN; HOSSEINZADEH ZAHRA; GHARAGOZLI KUROSH; KALANIE AMIR REZA; KAMGOOYAN MINA

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Journal: GENETICS IN THE 3RD MILLENNIUM Year:2011 | Volume:8 | Issue:4 Page(s): 2235-2239

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Title

HLA PROFILE AND CLINICAL PRESENTATION OF MULTIPLE SCLEROSIS IN IRAN

Author(s)

Keywords

HLAQ3

CLINICAL PRESENTATIONQ3

MULTIPLE SCLEROSISQ3

IRANQ3

Abstract

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, with unknown etiology in which both genetic and environmental factors are thought to be involved. The human leukocyte antigen (HLA) system provides a set of genetic markers which lend themselves to systematic study. In IRAN, HLA-A24, HLA-DR2, and HLA- DR15 are significantly increased in MS patients. The disease also has 3 main CLINICAL PRESENTATIONs, consisting of relapsing- remitting (88%) primary progressive (7%) and secondary progressive with a gender ratio of 2.5:1 (female: male) and a mean age at onset of 27+ 7.4 years in our country. Five percent of our patients had a positive family history for the disease, 14% of patients had benign MS, and 12% with disease duration longer than five years had an Expanded Disability Status Scale <2. The opticospinal form of MS was not a common form of presentation of the disease in IRAN.

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