A SURVEY ON MAJOR GENES AFFECTING OVULATION RATE AND PROLIFICACY OF SHEEP

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EGHBALSAID SHAHIN; TOGHYANI MAJID; GHAEDI KAMRAN; NASR ESFAHANI MOHAMMAD HOSSEIN

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Journal: GENETICS IN THE 3RD MILLENNIUM Year:2011 | Volume:8 | Issue:4 Page(s): 2169-2189

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Title

A SURVEY ON MAJOR GENES AFFECTING OVULATION RATE AND PROLIFICACY OF SHEEP

Author(s)

EGHBALSAID SHAHIN | TOGHYANI MAJID | GHAEDI KAMRAN | NASR ESFAHANI MOHAMMAD HOSSEIN | Issue Writer Certificate

Keywords

MAJOR GENESQ3

BMPR-1BQ3

GDF9Q2

BMP15Q3

OVULATION RATEQ3

PROLIFICACYQ2

Abstract

The fecundity performance in sheep has been interesting for producers due to its economical importance. The estimated heritability for this trait is low (less than 10%) in various reports. However, the genetic gain from direct selection of this trait is greater than expected from infinitesimal theory base. Segregation of major gene/genes effective on PROLIFICACY has been proposed as a main reason for this discrepancy. So far, mutations in some genes, all belonging to transforming growth factor b (TGF b), segregated in these flocks have been detected. The mutated genes in brief include: a) Booroola or Bone Morphogenetic Protein Receptor 1B (BMPR1-B) which is an autosomal gene with an additive effect on the OVULATION RATE and a partial dominance effect on litter size. b) Growth Differentiation Factor 9 (GDF9) which is another autosomal gene with an over-dominance effect so that homozygote mutant ewes are sterile. Eight mutations have been detected in this gene and the effect of each allele varies from 0.3 to 1.2 lambs per birth. c) Bone Morphogenetic Protein 15 (BMP15) is an overdominance sex-linked gene like GDF9. Ewes carrier for these fecundity genes keep their superiority over non-carrier ones in the whole life. Having mutations in two genes like BMP15 and BMPR-1B or BMP15 and GDF9 enhances the PROLIFICACY compared to single mutation owners. To date, the presence of mutation in both BMP15 and GDF9 in Iranian sheep breeds have been confirmed. However, none of them are associated with a significant effect on PROLIFICACY. The summation of single muations in each ewe might cause twining rate in these breeds. In this paper, we reviewd the history, mutations and the proposed action mechanism for these MAJOR GENES.

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APA: Copy

EGHBALSAID, SHAHIN, TOGHYANI, MAJID, GHAEDI, KAMRAN, & NASR ESFAHANI, MOHAMMAD HOSSEIN. (2011). A SURVEY ON MAJOR GENES AFFECTING OVULATION RATE AND PROLIFICACY OF SHEEP. GENETICS IN THE 3RD MILLENNIUM, 8(4), 2169-2189. SID. https://sid.ir/paper/117204/en

Vancouver: Copy

EGHBALSAID SHAHIN, TOGHYANI MAJID, GHAEDI KAMRAN, NASR ESFAHANI MOHAMMAD HOSSEIN. A SURVEY ON MAJOR GENES AFFECTING OVULATION RATE AND PROLIFICACY OF SHEEP. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2011;8(4):2169-2189. Available from: https://sid.ir/paper/117204/en

IEEE: Copy

SHAHIN EGHBALSAID, MAJID TOGHYANI, KAMRAN GHAEDI, and MOHAMMAD HOSSEIN NASR ESFAHANI, “A SURVEY ON MAJOR GENES AFFECTING OVULATION RATE AND PROLIFICACY OF SHEEP,” GENETICS IN THE 3RD MILLENNIUM, vol. 8, no. 4, pp. 2169–2189, 2011, [Online]. Available: https://sid.ir/paper/117204/en

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