TERATOGENIC EFFECTS OF A NEW QUINAZOLINONE DERIVATIVE ON THE DEVELOPMENT OF BALB/C MICE FETUSES ON DAYS 9 10 AND 11 OF GESTATION

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SHAMS LAHIJANI M.; AHMADZADEH F.; DABIRI M.

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Paper Information

Journal: IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A- SCIENCE Year:2006 | Volume:30 | Issue:A1 Page(s): 27-34

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Title

TERATOGENIC EFFECTS OF A NEW QUINAZOLINONE DERIVATIVE ON THE DEVELOPMENT OF BALB/C MICE FETUSES ON DAYS 9 10 AND 11 OF GESTATION

Author(s)

SHAMS LAHIJANI M. | AHMADZADEH F. | DABIRI M. | Issue Writer Certificate

Keywords

QUINAZOLINONEQ3

BALB/C MICE EMBRYOSQ3

ABNORMALITIESQ3

Abstract

For the first time, a spectrum of morphological ABNORMALITIES have been produced in developing mouse embryos (N=50), by injecting (IP) 75 and 100 mg/kg of maternal body weight of a new QUINAZOLINONE derivative, 4(3H)QUINAZOLINONE-2-propyl-2-phenylethyl(QPPE), on days 9, 10 and 11 of gestation. Measurements of the length of the crown-rump (CR), weight of body of the embryos and placenta on day 17 showed significant growth retardation (P<0.05) with day 9 being the critical day. The severity of the changes was dependent on the concentrations of QUINAZOLINONE, as higher doses created more abnormal embryos (syndactily, scaphocephaly, exocephaly, microcephaly, acrocephaly, abnormal polarity in lower and upper limbs, deviation of body axis, growth retardation) and placentas. Apparently QPPE acts on organogenesis on a specific phase of the developmental stage by expressing genes regulating mitosis and cell proliferation.

Cites

QUALITATIVE AND QUANTITATIVE ANALYSIS OF THE EFFECTS OF QUINAZOLINONES ON INTERNAL ORGANS OF NEWBORN BALB/C MICE

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APA: Copy

SHAMS LAHIJANI, M., AHMADZADEH, F., & DABIRI, M.. (2006). TERATOGENIC EFFECTS OF A NEW QUINAZOLINONE DERIVATIVE ON THE DEVELOPMENT OF BALB/C MICE FETUSES ON DAYS 9 10 AND 11 OF GESTATION. IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A- SCIENCE, 30(A1), 27-34. SID. https://sid.ir/paper/117922/en

Vancouver: Copy

SHAMS LAHIJANI M., AHMADZADEH F., DABIRI M.. TERATOGENIC EFFECTS OF A NEW QUINAZOLINONE DERIVATIVE ON THE DEVELOPMENT OF BALB/C MICE FETUSES ON DAYS 9 10 AND 11 OF GESTATION. IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A- SCIENCE[Internet]. 2006;30(A1):27-34. Available from: https://sid.ir/paper/117922/en

IEEE: Copy

M. SHAMS LAHIJANI, F. AHMADZADEH, and M. DABIRI, “TERATOGENIC EFFECTS OF A NEW QUINAZOLINONE DERIVATIVE ON THE DEVELOPMENT OF BALB/C MICE FETUSES ON DAYS 9 10 AND 11 OF GESTATION,” IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A- SCIENCE, vol. 30, no. A1, pp. 27–34, 2006, [Online]. Available: https://sid.ir/paper/117922/en

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