NEUROCOGNITIVE AND PSYCHOLOGIC BIO-MARKERS IN OLD PEOPLE IN MASHHAD, IRAN

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MANAVIFAR L.; NEMATI KARIMAVI H.A.; NEJAT SHOKOUHI A.; SHIRDEL A.; SHAKERI M.T.; MAHJOUB M.

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Journal: Iranian Journal of Epidemiology Year:2009 | Volume:5 | Issue:2 Page(s): 40-48

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Title

NEUROCOGNITIVE AND PSYCHOLOGIC BIO-MARKERS IN OLD PEOPLE IN MASHHAD, IRAN

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Keywords

COBALAMINQ2

FOLATEQ3

HOMOCYSTEINQ3

NEUROCOGNITIVE & PSYCHOLIGIC MARKERSQ3

ELDERLYQ3

Abstract

Background and Objectives: Incidence of neurocognitive and psychologic disorders in ELDERLY seems to become high There are numerous factors affecting neurocognitive functions like vascular factors, Vitamin B12 and FOLATE and HOMOCYSTEINe levels. The aim of this study was to assess the relation between neurocognitive- psychologic markers and HOMOCYSTEIN (Hcy), V.B12 (COBALAMIN) and FOLATE in serum.Methods: Two hundred eighty ELDERLY people admitted to Emam Reza Teaching Hospital in Mashahd, Iran. neurocognitive-psychologic disorders was diagnosed by a trained physician. Serum COBALAMIN, FOLATE and HOMOCYSTEIN measured by RIA and ELIZA methods, respectively.Results: Based on Hcy>15 mmol/l level, cut off point <330 pg/ml for serum COBALAMIN and <6.5 ng/ml for FOLATE deficiency defined as deficiency. The correlation between COBALAMIN and FOLATE was statistically significant (p=0.000). Hemocystein correlated inversely to COBALAMIN (p=0.001) and FOLATE (p=0.044). There were no statistical significant between COBALAMIN, FOLATE and Hcv>15µmol/l and neurocognitive & psychologic markers unless Deep Tendon reflex test (P=0.04). All patients with dementia had hyperhemocysteinemia.Conclusions: Despite the plausible biochemical mechanism, further diagnostic studies, based on clinical, neuropsychological, laboratory features will be necessary to better understand this fascinating biochemical challenge.

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APA: Copy

MANAVIFAR, L., NEMATI KARIMAVI, H.A., NEJAT SHOKOUHI, A., SHIRDEL, A., SHAKERI, M.T., & MAHJOUB, M.. (2009). NEUROCOGNITIVE AND PSYCHOLOGIC BIO-MARKERS IN OLD PEOPLE IN MASHHAD, IRAN. IRANIAN JOURNAL OF EPIDEMIOLOGY, 5(2), 40-48. SID. https://sid.ir/paper/120689/en

Vancouver: Copy

MANAVIFAR L., NEMATI KARIMAVI H.A., NEJAT SHOKOUHI A., SHIRDEL A., SHAKERI M.T., MAHJOUB M.. NEUROCOGNITIVE AND PSYCHOLOGIC BIO-MARKERS IN OLD PEOPLE IN MASHHAD, IRAN. IRANIAN JOURNAL OF EPIDEMIOLOGY[Internet]. 2009;5(2):40-48. Available from: https://sid.ir/paper/120689/en

IEEE: Copy

L. MANAVIFAR, H.A. NEMATI KARIMAVI, A. NEJAT SHOKOUHI, A. SHIRDEL, M.T. SHAKERI, and M. MAHJOUB, “NEUROCOGNITIVE AND PSYCHOLOGIC BIO-MARKERS IN OLD PEOPLE IN MASHHAD, IRAN,” IRANIAN JOURNAL OF EPIDEMIOLOGY, vol. 5, no. 2, pp. 40–48, 2009, [Online]. Available: https://sid.ir/paper/120689/en

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