THE EFFECTS OF DARK CHOCOLATE ON LIPID PROFILE, APO-LIPOPROTEIN A-1, APO-LIPOPROTEIN B AND INFLAMMATION IN TYPE-2 DIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL

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HAGHIGHAT N.; ROSTAMI A.; EGHTESADI SH.; SHIDFAR F.; HEIDARI I.; HOSEINI A.F.

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Journal: JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY Year:2013 | Volume:8 | Issue:2 Page(s): 21-30

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Title

THE EFFECTS OF DARK CHOCOLATE ON LIPID PROFILE, APO-LIPOPROTEIN A-1, APO-LIPOPROTEIN B AND INFLAMMATION IN TYPE-2 DIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL

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Keywords

DARK CHOCOLATEQ3

LIPID PROFILEQ3

INFLAMMATIONQ3

APOLIPOPROTEINQ3

TYPE-2 DIABETESQ3

Abstract

Background and objective: DARK CHOCOLATE has received the attention of researchers due to its cardiovascular protective effects. The purpose of this study was to determine the effects of 8 weeks consumption of DARK CHOCOLATE on the LIPID PROFILE, apo-lipoprotein A-1 (Apo A1), apo-lipoprotein B (Apo B), and hs-CRP in type-2 diabetic patients.Materials and methods: This clinical trial was conducted on 69 diabetic patients randomly assigned to one of two (intervention and control) groups. The intervention (n=32) and control (n=28) groups received daily, for 8 weeks, 25 gr DARK CHOCOLATE (containing 450mg polyphenols) and a similar amount of white chocolate, respectively. At the beginning and at the end of the period, blood samples were collected to measure total cholesterol, LDL-c, HDL-c, TG, Apo A1, Apo B, and hs-CRP. In addition, anthropometric measurements were made and data were gathered on physical activity, blood pressure and food intake and compared between the 2 groups.Results: The intervention brought about statistically significant reductions in the blood levels of TG (p=0.007), apo-lipoprotein A-1 (p=0.045), apo-lipoprotein B (p=0.01) and hs-CRP (p=0.005).There were no significant differences in either group with regard to serum total cholesterol, LDL-c or HDL-c levels at the end of the period; neither were observed any intergroup differences.Conclusion: The findings suggest that polyphenol-rich DARK CHOCOLATE may have desirable effects on the blood triglyceride, apo-lipoproteins A-1 and B and hs-CRP levels in diabetic patients, with no effect on the LIPID PROFILE.

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APA: Copy

HAGHIGHAT, N., ROSTAMI, A., EGHTESADI, SH., SHIDFAR, F., HEIDARI, I., & HOSEINI, A.F.. (2013). THE EFFECTS OF DARK CHOCOLATE ON LIPID PROFILE, APO-LIPOPROTEIN A-1, APO-LIPOPROTEIN B AND INFLAMMATION IN TYPE-2 DIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 8(2), 21-30. SID. https://sid.ir/paper/121427/en

Vancouver: Copy

HAGHIGHAT N., ROSTAMI A., EGHTESADI SH., SHIDFAR F., HEIDARI I., HOSEINI A.F.. THE EFFECTS OF DARK CHOCOLATE ON LIPID PROFILE, APO-LIPOPROTEIN A-1, APO-LIPOPROTEIN B AND INFLAMMATION IN TYPE-2 DIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2013;8(2):21-30. Available from: https://sid.ir/paper/121427/en

IEEE: Copy

N. HAGHIGHAT, A. ROSTAMI, SH. EGHTESADI, F. SHIDFAR, I. HEIDARI, and A.F. HOSEINI, “THE EFFECTS OF DARK CHOCOLATE ON LIPID PROFILE, APO-LIPOPROTEIN A-1, APO-LIPOPROTEIN B AND INFLAMMATION IN TYPE-2 DIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 8, no. 2, pp. 21–30, 2013, [Online]. Available: https://sid.ir/paper/121427/en

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