EFFECT OF CELLULAR SENESCENCE ON INSULIN RESISTANCE IN DIET-INDUCED OBESE WISTAR RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

CHERAGHPOUR M.; SHAHBAZI R.; HOMAYOUNFAR R.; IMANI H.; ZAND H.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY Year:2015 | Volume:10 | Issue:1 Page(s): 1-8

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

872

Download:

Cites:

Information Journal Paper

Title

EFFECT OF CELLULAR SENESCENCE ON INSULIN RESISTANCE IN DIET-INDUCED OBESE WISTAR RATS

Author(s)

Keywords

CELLULAR SENESCENCEQ2

DIET-INDUCED OBESITYQ2

INSULIN RESISTANCEQ2

Abstract

Background and Objectives: CELLULAR SENESCENCE has been known as a tumor suppressor mechanism; however, some evidence shows that CELLULAR SENESCENCE is an inducer factor for metabolic disorders, such as INSULIN RESISTANCE and diabetes. In this study, the effect of senescence was assayed in the peripheral tissues of diet-induced obese rats.Materials and Methods: 30 male 5-week old wistar rats were randomly assigned into high-calorie diet through 416 kcal/100 g (researcher made) or control diet for 12 weeks. Weight changes, lipid profile, glucose, insulin levels and QUICKI (Quantitative Insulin Sensitivity Check Index) index were measured at the end of the 12th week. Also the tissue samples were isolated, and immune-blotting was performed to identify proteins P16INK4a and P53 (cell senescence markers).Results: P53 levels in the fat tissue and other peripheral tissues of obese rats were significantly higher compared to the control group. P16INK4a expression was increased only in fat tissue but protein was not expressed in other tissues. In the obese rats, the serum levels of glucose (183.60±34.90 vs. 152.40±15.48 P=0.019), cholesterol (60.70±6.88 vs.46.60±7.82 P<0.001) and triglyceride (124.60±46.43 vs. 57.20±24.02 P<0.001) were more than in the control group but The QUICKI index was significantly lower in the obese rats compared to the control group (p=0.01).Conclusion: Our results suggest that cell senescence in fat tissue can be predisposed to the development of INSULIN RESISTANCE and age-related diseases by generating some alternation in the fat tissue.

Cites

No record.

References

Cite

APA: Copy

CHERAGHPOUR, M., SHAHBAZI, R., HOMAYOUNFAR, R., IMANI, H., & ZAND, H.. (2015). EFFECT OF CELLULAR SENESCENCE ON INSULIN RESISTANCE IN DIET-INDUCED OBESE WISTAR RATS. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 10(1), 1-8. SID. https://sid.ir/paper/121476/en

Vancouver: Copy

CHERAGHPOUR M., SHAHBAZI R., HOMAYOUNFAR R., IMANI H., ZAND H.. EFFECT OF CELLULAR SENESCENCE ON INSULIN RESISTANCE IN DIET-INDUCED OBESE WISTAR RATS. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2015;10(1):1-8. Available from: https://sid.ir/paper/121476/en

IEEE: Copy

M. CHERAGHPOUR, R. SHAHBAZI, R. HOMAYOUNFAR, H. IMANI, and H. ZAND, “EFFECT OF CELLULAR SENESCENCE ON INSULIN RESISTANCE IN DIET-INDUCED OBESE WISTAR RATS,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 10, no. 1, pp. 1–8, 2015, [Online]. Available: https://sid.ir/paper/121476/en

Related Journal Papers