Comparative Evaluation of the Presence of Connective Stroma Myofibroblasts and Mast Cells in Odontogenic Keratocyst, Odontogenic Myxoma and Adenomatoid Odontogenic Tumor

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TORABINIA NAKISA; KARGAHI NEDA; Goli Razieh

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Journal: JOURNAL OF ISFAHAN DENTAL SCHOOL Year:2019 | Volume:15 | Issue:2 Page(s): 148-155

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Title

Comparative Evaluation of the Presence of Connective Stroma Myofibroblasts and Mast Cells in Odontogenic Keratocyst, Odontogenic Myxoma and Adenomatoid Odontogenic Tumor

Author(s)

TORABINIA NAKISA | KARGAHI NEDA | Goli Razieh | Issue Writer Certificate

Keywords

Adenomatoidodontogenic tumorQ1

Connective tissue stromaQ1

Mast cellQ2

MyofibroblastQ1

OdontogenickeratocystQ1

OdontogenicmyxomaQ2

Abstract

Introduction: Odontogenic cysts and tumors are important jaw lesions. Sometimes their behavior is influenced by non-epithelial factors. Myofibroblasts are specific cells of the stroma. Mast cells affect the differentiation and function of Myofibroblasts. Regarding the importance of stroma in the progression of tumors, the present study examined the presence of Mast cells and Myofibroblasts and their effects on Odontogenickeratocyst (OKC), Odontogenicmyxoma (OM) and Adenomatoidodontogenic tumor (AOT). Materials & Methods: In this cross-sectional descriptive-analytical study, 10 blocks of OM, 7 blocks of OKC and 6 AOT blocks from the Archives of the Department of Pathology, Isfahan Dental School, were stained with α SMA immunohistochemistry marker and toluidine blue histochemical marker. The mean number of Myofibroblasts and Mast cells, the color pattern of Myofibroblasts and the severity of inflammation of the lesions were evaluated. Data was analyzed by SPSS 20 using Kruskal-Wallis, Mann-Whitney and chi-squared tests (α = 0. 05). Results: The degree of Myofibroblast staining was not significantly different between the lesions (p value = 0. 55), but the severity of inflammation was significantly different (p value = 0. 02). The severity of inflammation in OKC was significantly higher than AOT (p value = 0. 025) and OM (p value = 0. 023) but there was no significant difference between AOT and OM lesions (p value = 0. 87). There was a significant difference between the distribution patterns of the lesions (p value = 0. 015). The frequency of the focal pattern in the OKC was minimal. The number of intact (p value = 0. 72), degranulated (p value = 0. 69) and total (p value = 0. 75) Mast cells were not significantly different between the lesions. Conclusion: There were no significant differences in the number of Mast cells and Myofibroblasts between the lesions, but myofibrroblasts were expressed with higher levels in OM, which is more invasive.

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APA: Copy

TORABINIA, NAKISA, KARGAHI, NEDA, & Goli, Razieh. (2019). Comparative Evaluation of the Presence of Connective Stroma Myofibroblasts and Mast Cells in Odontogenic Keratocyst, Odontogenic Myxoma and Adenomatoid Odontogenic Tumor. JOURNAL OF ISFAHAN DENTAL SCHOOL, 15(2 ), 148-155. SID. https://sid.ir/paper/126170/en

Vancouver: Copy

TORABINIA NAKISA, KARGAHI NEDA, Goli Razieh. Comparative Evaluation of the Presence of Connective Stroma Myofibroblasts and Mast Cells in Odontogenic Keratocyst, Odontogenic Myxoma and Adenomatoid Odontogenic Tumor. JOURNAL OF ISFAHAN DENTAL SCHOOL[Internet]. 2019;15(2 ):148-155. Available from: https://sid.ir/paper/126170/en

IEEE: Copy

NAKISA TORABINIA, NEDA KARGAHI, and Razieh Goli, “Comparative Evaluation of the Presence of Connective Stroma Myofibroblasts and Mast Cells in Odontogenic Keratocyst, Odontogenic Myxoma and Adenomatoid Odontogenic Tumor,” JOURNAL OF ISFAHAN DENTAL SCHOOL, vol. 15, no. 2 , pp. 148–155, 2019, [Online]. Available: https://sid.ir/paper/126170/en

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