Evaluation of Salivary Interleukin-6 Levels in Children with Mild and Severe Early Childhood Caries before and Three Months after Treatment

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Kasaie Koupaie Samira; JAVADINEJAD SHAHRZAD; RASHIDI MEYBODI FATEMEH

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Journal: JOURNAL OF ISFAHAN DENTAL SCHOOL Year:2020 | Volume:16 | Issue:1 Page(s): 22-30

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Title

Evaluation of Salivary Interleukin-6 Levels in Children with Mild and Severe Early Childhood Caries before and Three Months after Treatment

Author(s)

Kasaie Koupaie Samira | JAVADINEJAD SHAHRZAD | RASHIDI MEYBODI FATEMEH | Issue Writer Certificate

Keywords

Dental cariesQ2

Interleukin-6Q1

SalivaQ2

Abstract

Introduction: To evaluate and compare Salivary IL6 level in children with early childhood caries, before and 3 months after treatment. Materials & Methods: In this study totally 32 children aged 3 to 6 years (12 without any caries, 10 with mild caries: 1 < dmft < 4, 10 with severe caries: dmft > 5) were included. Salivary samples were taken from all children at least 1 hour after eating food. The group with severe ECC were treated as a full-mouth rehabilitation under general anesthesia. The group with mild ECC were treated in clinic. Group with no ECC followed with no treatment. 3 months after full-mouth rehabalitation, Salivary samples gathered again. Data analysis was performed using Kolmogorov-Smirnov, Wilcoxon, Kruskal Wallis tests with SPSS version 22 software. Results: Baseline IL6 was higher in patients with severe ECC (p value = 0. 007 and P = 0. 001) but there was no statistically significant difference in baseline levels between first two groups. (p value = 0. 059). After treatment only severe ECC group had statistically significant difference of Salivary IL6 after treatment. (p value = 0. 007). Conclusion: Our findings show that Salivary IL6 level could be a partial predictor of ECC lesions. Treatment in sever ECC caused statistically significant decrease in IL6 but IL6 change was not significant in mild group.

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References

Early childhood caries: A review

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APA: Copy

Kasaie Koupaie, Samira, JAVADINEJAD, SHAHRZAD, & RASHIDI MEYBODI, FATEMEH. (2020). Evaluation of Salivary Interleukin-6 Levels in Children with Mild and Severe Early Childhood Caries before and Three Months after Treatment. JOURNAL OF ISFAHAN DENTAL SCHOOL, 16(1 ), 22-30. SID. https://sid.ir/paper/126417/en

Vancouver: Copy

Kasaie Koupaie Samira, JAVADINEJAD SHAHRZAD, RASHIDI MEYBODI FATEMEH. Evaluation of Salivary Interleukin-6 Levels in Children with Mild and Severe Early Childhood Caries before and Three Months after Treatment. JOURNAL OF ISFAHAN DENTAL SCHOOL[Internet]. 2020;16(1 ):22-30. Available from: https://sid.ir/paper/126417/en

IEEE: Copy

Samira Kasaie Koupaie, SHAHRZAD JAVADINEJAD, and FATEMEH RASHIDI MEYBODI, “Evaluation of Salivary Interleukin-6 Levels in Children with Mild and Severe Early Childhood Caries before and Three Months after Treatment,” JOURNAL OF ISFAHAN DENTAL SCHOOL, vol. 16, no. 1 , pp. 22–30, 2020, [Online]. Available: https://sid.ir/paper/126417/en

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