FORMULATION OF DIPHENHYDRAMINE MUCOADHESIVE PASTE AND EVALUATION OF IT'S PHYSICOCHEMICAL CHARACTERISTICS

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KHAZAELI P.; AJILCHI H.

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Paper Information

Journal: Jundishapur Scientific Medical Journal Year:2006 | Volume:4 | Issue:4 (47) Page(s): 341-352

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Title

FORMULATION OF DIPHENHYDRAMINE MUCOADHESIVE PASTE AND EVALUATION OF IT'S PHYSICOCHEMICAL CHARACTERISTICS

Author(s)

KHAZAELI P. | AJILCHI H. | Issue Writer Certificate

Keywords

DIPHENHYDRAMINEQ4

MUCOADHESIVEQ2

APHTHOUS ULCERQ3

Abstract

Objectives: Aphthous stomatitis is one of the common mouth problems. Several medical procedures have been suggested for its treatment. DIPHENHYDRAMINE has been commonly used to control aphthous pain because of its local anaesthetic effect. One of the important factors that determine its effectiveness in the treatment of APHTHOUS ULCER is persistent at the location. Some of MUCOADHESIVE drug formulations such as Adcortyl (containing corticosteroids) have several inherent side effects like candidiasis. The purpose of this research was to prepare a MUCOADHESIVE formulation of DIPHENHYDRAMINE in a suitable base which can be used in the treatment of aphthous stomatitis.Methods: In the first stage, low-density propylene glycol (LDPE) and liquid paraffin were used for preparing the plastibase by shock cooling method. This base was quality-tested and the suitable method to prepare the MUCOADHESIVE base was determined. In the second stage of work, ten formulations. containing different concentrations of gelatine, pectin, Na-CMC were prepared. The adhesive strengths, the occlusivity and the spreadability of the pastes were studied. The selected preparations were tested for drug release studies by Franz diffusion cell.Results: The results showed that the selected formulation has the adhesive strengths equal to 109 mNcm-2 similar to the commercial product with a release drug flux rate of 6.7µg/cm2 min.Conclusions: These results showed that DIPHENHYDRAMINE can be formulated in a MUCOADHESIVE base with proper mucoadherence, exclusivity, occlusivity spreadability with suitable release profile that makes it useful for use in aphthous stomatitis.

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References

IN VITROSTUDY OF SOME FACTORS AFFECTING THE ADHESIVE STRENGTH OF MUCOADHESIVE POLYMERS

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APA: Copy

KHAZAELI, P., & AJILCHI, H.. (2006). FORMULATION OF DIPHENHYDRAMINE MUCOADHESIVE PASTE AND EVALUATION OF IT'S PHYSICOCHEMICAL CHARACTERISTICS. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 4(4 (47)), 341-352. SID. https://sid.ir/paper/12746/en

Vancouver: Copy

KHAZAELI P., AJILCHI H.. FORMULATION OF DIPHENHYDRAMINE MUCOADHESIVE PASTE AND EVALUATION OF IT'S PHYSICOCHEMICAL CHARACTERISTICS. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2006;4(4 (47)):341-352. Available from: https://sid.ir/paper/12746/en

IEEE: Copy

P. KHAZAELI, and H. AJILCHI, “FORMULATION OF DIPHENHYDRAMINE MUCOADHESIVE PASTE AND EVALUATION OF IT'S PHYSICOCHEMICAL CHARACTERISTICS,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 4, no. 4 (47), pp. 341–352, 2006, [Online]. Available: https://sid.ir/paper/12746/en

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