A STUDY OF CORRELATION BETWEEN CLINICAL SEVERITY WITH LABORATORY DATA IN SICKLE CELL DISEASE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KADKHODAEI ELYADERANI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Jundishapur Scientific Medical Journal Year:2006 | Volume:4 | Issue:4 (47) Page(s): 279-287

Download Full-Text

Persian Verion

View:

1,535

Download:

Cites:

Information Journal Paper

Title

A STUDY OF CORRELATION BETWEEN CLINICAL SEVERITY WITH LABORATORY DATA IN SICKLE CELL DISEASE

Author(s)

KADKHODAEI ELYADERANI M. | Issue Writer Certificate

Keywords

SICKLE CELL DISEASEQ3

SEVERITY RED CELL INDICESQ2

HPLCQ4

Abstract

Objectives: SICKLE CELL DISEASE is an inherited red cell disorder characterized by diverse clinical courses. Some individual patients follow a more severe course that begins shortly after birth, whereas others are infrequently ill. The purpose of this work was to study the correlation between clinical severity with laboratory data in SICKLE CELL DISEASE patients in the hope to find data that can be used to predict the severity of clinical episode of SICKLE CELL DISEASE and therefore preclude the application of unnecessary interventions which are only needed for severe episodes.Methods: In this study, during one year period, 78 patients suffering from SICKLE CELL DISEASE (48 HbSS, 21 SC, 9 βthalassaemia) who attended the Haematology Clinic at the Department of Clinical Haematology of Manchester Royal Infirmary in England were studied. Red cell indices and haemoglobin analysis were examined when the patients were in their steady state. Red cell indices were determined using Syismax NE 8000, and haemoglobin variants (HbA2, HbC, HbS, HbA and HbF) were identified by fully automated Bio Rad HPLC, The patients were categorized as severe mild and moderate according to their clinical states. Correlation between clinical severity and laboratory data was assessed using multivariate statistical methods.Results: The results, as expected, showed a significant correlation, at p <0.05, in the whole group of phenotype with the total Hb, HbS, HbC. There was a positive correlation (r=0.32, p<0.05) between clinical severity and HbS level in all patient groups and negative correlation (r=-0.41, P<0.05) between clinical severity and HbF level in the SS but not in the SC or S-βthal patients.Conclusions: The high level of HbF, found in all patient groups, therefore could not be the underlying reason for the amelioration of the clinical severity and there must be other factors such as genetic, nutrition and immunity that might affect the clinical status of sickle cell patients.

Cites

No record.

References

No record.

Cite

APA: Copy

KADKHODAEI ELYADERANI, M.. (2006). A STUDY OF CORRELATION BETWEEN CLINICAL SEVERITY WITH LABORATORY DATA IN SICKLE CELL DISEASE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 4(4 (47)), 279-287. SID. https://sid.ir/paper/12747/en

Vancouver: Copy

KADKHODAEI ELYADERANI M.. A STUDY OF CORRELATION BETWEEN CLINICAL SEVERITY WITH LABORATORY DATA IN SICKLE CELL DISEASE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2006;4(4 (47)):279-287. Available from: https://sid.ir/paper/12747/en

IEEE: Copy

M. KADKHODAEI ELYADERANI, “A STUDY OF CORRELATION BETWEEN CLINICAL SEVERITY WITH LABORATORY DATA IN SICKLE CELL DISEASE,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 4, no. 4 (47), pp. 279–287, 2006, [Online]. Available: https://sid.ir/paper/12747/en

Related Journal Papers