VALIDATION OF MODEL SIMULATIONS OF AIR FLOW IN CLEANROOMS: CASE OF A PHARMACEUTICAL INDUSTRY

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DAMIRI ZABIHOLLAH; YARAHMADI RASOUL; RASHIDI MITRA

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Journal: IRAN OCCUPATIONAL HEALTH JOURNAL Year:2017 | Volume:14 | Issue:4 Page(s): 23-35

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Title

VALIDATION OF MODEL SIMULATIONS OF AIR FLOW IN CLEANROOMS: CASE OF A PHARMACEUTICAL INDUSTRY

Author(s)

DAMIRI ZABIHOLLAH | YARAHMADI RASOUL | RASHIDI MITRA | Issue Writer Certificate

Keywords

RNG K-ε TURBULENCE MODELQ1

CLEANROOMQ1

AIRFLOWQ1

FLUENTQ1

Abstract

Background and aims: The concentration of airborne particles is under the control because of an important role in the production of drugs and high-tech products. Air flow pattern in the CLEANROOM is one of the important parameters of particle concentration and distribution of air pollution and need to be accurately modeled. Therefore in this study, evaluation and simulation of air flow patterns was investigated in CLEANROOM.Methods: This study is an experimental and applied research, which was conducted in 2015 within a pharmaceutical industry. This study was to determine the air flow pattern in CLEANROOM. In this study, 3 clean room with 3 cleanliness classes B, C and D were studied.Then, the air flow pattern in the clean room, to determine the velocity vectors were simulated by computational fluid dynamics techniques (CFD).Results: The findings of this study showed that air flow rate measured in experimental models with air flow rates predicted by CFD software under the same conditions and at the same spacing are very close to each other. Also AIRFLOW velocity contours for 3 the cleanliness class were determined. In addition, the results of measuring particle concentration in clean rooms shows the mean concentration of particulate contamination in three classes’ cleanliness, were lower than limit of the standard ISO 14644.Conclusion: This study showed that RNG K-e turbulence model was the most appropriate model to simulate air flow pattern in the CLEANROOM. Moreover equipment and tools in a CLEANROOM affected on the pattern of air flow and ultimately the particle removal efficiency.

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APA: Copy

DAMIRI, ZABIHOLLAH, YARAHMADI, RASOUL, & RASHIDI, MITRA. (2017). VALIDATION OF MODEL SIMULATIONS OF AIR FLOW IN CLEANROOMS: CASE OF A PHARMACEUTICAL INDUSTRY. IRAN OCCUPATIONAL HEALTH JOURNAL, 14(4 ), 23-35. SID. https://sid.ir/paper/128948/en

Vancouver: Copy

DAMIRI ZABIHOLLAH, YARAHMADI RASOUL, RASHIDI MITRA. VALIDATION OF MODEL SIMULATIONS OF AIR FLOW IN CLEANROOMS: CASE OF A PHARMACEUTICAL INDUSTRY. IRAN OCCUPATIONAL HEALTH JOURNAL[Internet]. 2017;14(4 ):23-35. Available from: https://sid.ir/paper/128948/en

IEEE: Copy

ZABIHOLLAH DAMIRI, RASOUL YARAHMADI, and MITRA RASHIDI, “VALIDATION OF MODEL SIMULATIONS OF AIR FLOW IN CLEANROOMS: CASE OF A PHARMACEUTICAL INDUSTRY,” IRAN OCCUPATIONAL HEALTH JOURNAL, vol. 14, no. 4 , pp. 23–35, 2017, [Online]. Available: https://sid.ir/paper/128948/en

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