TOXICITY ASSESSMENT OF CHEMICAL CONTAMINANTS; TRANSITION FROM IN VITRO METHODS TO NOVEL IN VITRO METHOD

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BAKAND SH.; AMERI AHMAD; FARSHAD A.A.

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Journal: IRAN OCCUPATIONAL HEALTH JOURNAL Year:2007 | Volume:4 | Issue:1-2 Page(s): 29-35

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Title

TOXICITY ASSESSMENT OF CHEMICAL CONTAMINANTS; TRANSITION FROM IN VITRO METHODS TO NOVEL IN VITRO METHOD

Author(s)

BAKAND SH. | AMERI AHMAD | FARSHAD A.A. | Issue Writer Certificate

Keywords

CHEMICAL CONTAMINANTSQ4

RISK ASSESSMENTQ4

TOXICOLOGYQ4

IN VITROQ4

IN VIVOQ4

Abstract

Exposure to occupational and environmental contaminants is a major contributor to human health problems. Despite significant achievements in the RISK ASSESSMENT of chemicals, the toxicological database, particularly for industrial chemicals, remains limited. Considering there are approximately 80, 000 chemicals in commerce, and an extremely large number of chemical mixtures, IN VIVO testing of this large number is unachievable from ethical, economical and scientific perspectives. Therefore, increasing the number of available industrial chemicals and new products has created a demand for alternatives to animal methods for better safety evaluation. Recent toxicity studies have demonstrated that IN VITRO methods are capable of rapidly providing toxicity information. In this review, current toxicity test methods for risk evaluation of industrial CHEMICAL CONTAMINANTS are presented. To evaluate the potential applications of IN VITRO methods, more recent test methods developed for toxicity testing of CHEMICAL CONTAMINANTS are discussed. Although IN VITRO TOXICOLOGY methods cannot exactly mimic the biodynamics of the whole body, IN VITRO test systems in combination with the knowledge of quantitative structure activity relationships (QSARs) and physiologically based toxicokinetic (PBTK) models have a potential to be considered more broadly for RISK ASSESSMENT of human chemical exposures.

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APA: Copy

BAKAND, SH., AMERI, AHMAD, & FARSHAD, A.A.. (2007). TOXICITY ASSESSMENT OF CHEMICAL CONTAMINANTS; TRANSITION FROM IN VITRO METHODS TO NOVEL IN VITRO METHOD. IRAN OCCUPATIONAL HEALTH JOURNAL, 4(1-2), 29-35. SID. https://sid.ir/paper/129239/en

Vancouver: Copy

BAKAND SH., AMERI AHMAD, FARSHAD A.A.. TOXICITY ASSESSMENT OF CHEMICAL CONTAMINANTS; TRANSITION FROM IN VITRO METHODS TO NOVEL IN VITRO METHOD. IRAN OCCUPATIONAL HEALTH JOURNAL[Internet]. 2007;4(1-2):29-35. Available from: https://sid.ir/paper/129239/en

IEEE: Copy

SH. BAKAND, AHMAD AMERI, and A.A. FARSHAD, “TOXICITY ASSESSMENT OF CHEMICAL CONTAMINANTS; TRANSITION FROM IN VITRO METHODS TO NOVEL IN VITRO METHOD,” IRAN OCCUPATIONAL HEALTH JOURNAL, vol. 4, no. 1-2, pp. 29–35, 2007, [Online]. Available: https://sid.ir/paper/129239/en

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