THE EFFECT OF THE HYDROALCOHOLIC EXTRACT OF GINSENG ON DETOXIFYING CYCLOPHOSPHAMIDE IN THE OVARY TISSUE OF ADULT FEMALE RATS

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NAZARI F.; JOHARI H.; HEMAYATKHAH JAHROMI V.; KARGAR JAHROMI H.; SAMANI JAHROMI E.

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Journal: Pars Journal of Medical Sciences Year:2014 | Volume:12 | Issue:3 Page(s): 23-30

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Title

THE EFFECT OF THE HYDROALCOHOLIC EXTRACT OF GINSENG ON DETOXIFYING CYCLOPHOSPHAMIDE IN THE OVARY TISSUE OF ADULT FEMALE RATS

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Keywords

GINSENGQ2

CYCLOPHOSPHAMIDEQ2

RATQ2

OVARYQ2

Abstract

Introduction: GINSENG is a medicinal herb. CYCLOPHOSPHAMIDE is also an anti-cancer drug with side effects on the ovaries. The purpose of this study is to investigate the effect of the hydroalcoholic extract of GINSENG on detoxifying CYCLOPHOSPHAMIDE in the OVARY tissue of adult female RATs.Materials & Methods: The present experimental study was conducted on 56 adult female RATs. The RATs were randomly divided into 7 groups of 8 each, including the negative control group, the sham control group and the experimental groups 1, 2, 3, 4 and 5. The negative control group received no drugs, while the sham control group was given solvent. Experimental groups 1, 2 and 3 received a daily dose of 5 mg/kg/bw CYCLOPHOSPHAMIDE and an additional dose of 0.5, 1 and 2 g/kg/bw GINSENG extract. Experimental group 4 received a daily dose of 5 mg/kg/bw CYCLOPHOSPHAMIDE and experimental group 5 received a daily dose of 2 g/kg/bw GINSENG extract. Their OVARY tissue sections were then prepared and examined.Results: In experimental group 1, follicular atresia occurred to a great extent; however, in experimental group 2, the extent of follicular atresia and tissue destruction was observed to be lower than in experimental group 1. In experimental group 3, follicular atresia reduced compared to in experimental groups 1 and 2, but in experimental group 4, follicular atresia occurred to a much greater extent. In experimental group 5, the number of graafian, primary and secondary follicles increased compared to the negative control group.Conclusions: CYCLOPHOSPHAMIDE increases the extent of follicular atresia, while the hydroalcoholic extract of GINSENG prevents the side effects of CYCLOPHOSPHAMIDE from setting in and thereby reduces the extent of follicular atresiafollicles.

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APA: Copy

NAZARI, F., JOHARI, H., HEMAYATKHAH JAHROMI, V., KARGAR JAHROMI, H., & SAMANI JAHROMI, E.. (2014). THE EFFECT OF THE HYDROALCOHOLIC EXTRACT OF GINSENG ON DETOXIFYING CYCLOPHOSPHAMIDE IN THE OVARY TISSUE OF ADULT FEMALE RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 12(3), 23-30. SID. https://sid.ir/paper/130874/en

Vancouver: Copy

NAZARI F., JOHARI H., HEMAYATKHAH JAHROMI V., KARGAR JAHROMI H., SAMANI JAHROMI E.. THE EFFECT OF THE HYDROALCOHOLIC EXTRACT OF GINSENG ON DETOXIFYING CYCLOPHOSPHAMIDE IN THE OVARY TISSUE OF ADULT FEMALE RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2014;12(3):23-30. Available from: https://sid.ir/paper/130874/en

IEEE: Copy

F. NAZARI, H. JOHARI, V. HEMAYATKHAH JAHROMI, H. KARGAR JAHROMI, and E. SAMANI JAHROMI, “THE EFFECT OF THE HYDROALCOHOLIC EXTRACT OF GINSENG ON DETOXIFYING CYCLOPHOSPHAMIDE IN THE OVARY TISSUE OF ADULT FEMALE RATS,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 12, no. 3, pp. 23–30, 2014, [Online]. Available: https://sid.ir/paper/130874/en

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