THE RELATIONSHIP BETWEEN RS587777844 KISS1R GENE POLYMORPHISM AND INFERTILITY IN WOMEN FROM GUILAN PROVINCE

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SIAHPOOSH ZAKIEH; VAZIRI HAMIDREZA; Roohi Hossein

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Journal: Pars Journal of Medical Sciences Year:2017 | Volume:15 | Issue:1 Page(s): 16-22

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Title

THE RELATIONSHIP BETWEEN RS587777844 KISS1R GENE POLYMORPHISM AND INFERTILITY IN WOMEN FROM GUILAN PROVINCE

Author(s)

SIAHPOOSH ZAKIEH | VAZIRI HAMIDREZA | Roohi Hossein | Issue Writer Certificate

Keywords

INFERTILITYQ2

KISS1R GENEQ1

POLYMORPHISMQ2

WOMENQ2

Abstract

Introduction: KISS1R GENE is responsible for wide ranges of diseases including cancer and INFERTILITY. Mutations in the KISS1R GENE are one of the most important potential causes of INFERTILITY. KISS1R has an important role in regulating the hypothalamic-pituitary-gonadal axis that regulates reproduction and maturation in vertebrates. This study aimed to evaluate the relationship between rs587777844 KISS1R GENE POLYMORPHISM and female INFERTILITY in Guilan Province.Materials & Methods: Blood samples were obtained from 40 infertile WOMEN as cases and 40 healthy WOMEN as controls. Genomic DNA was extracted from peripheral blood leukocytes and allele specific PCR (AS-PCR) method was used for determining codon variations. Data were analyzed in Medcalc software (v 13.0).Results: Results showed a significant relationship in distribution of genotypes (P=0.03) and allele frequencies between the two groups (p=0.0113).Conclusion: Results showed a significant relationship in distribution of genotypes (P=0.03) and allele frequencies between the two groups (p=0.0113).

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APA: Copy

SIAHPOOSH, ZAKIEH, VAZIRI, HAMIDREZA, & Roohi, Hossein. (2017). THE RELATIONSHIP BETWEEN RS587777844 KISS1R GENE POLYMORPHISM AND INFERTILITY IN WOMEN FROM GUILAN PROVINCE. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 15(1 ), 16-22. SID. https://sid.ir/paper/130933/en

Vancouver: Copy

SIAHPOOSH ZAKIEH, VAZIRI HAMIDREZA, Roohi Hossein. THE RELATIONSHIP BETWEEN RS587777844 KISS1R GENE POLYMORPHISM AND INFERTILITY IN WOMEN FROM GUILAN PROVINCE. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2017;15(1 ):16-22. Available from: https://sid.ir/paper/130933/en

IEEE: Copy

ZAKIEH SIAHPOOSH, HAMIDREZA VAZIRI, and Hossein Roohi, “THE RELATIONSHIP BETWEEN RS587777844 KISS1R GENE POLYMORPHISM AND INFERTILITY IN WOMEN FROM GUILAN PROVINCE,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 15, no. 1 , pp. 16–22, 2017, [Online]. Available: https://sid.ir/paper/130933/en

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