EFFECT OF CATECHIN ON SERUM LEVELS OF INFLAMMATORY CYTOKINES, ANTIOXIDANT ENZYMES ACTIVITY AND DNA OXIDATIVE DAMAGE OF OVARIAN TISSUE IN POLYCYSTIC OVARIAN SYNDROME RAT MODEL

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Rahbarian Raheleh; SADOUGHI SEYED DAMOON

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Journal: Pars Journal of Medical Sciences Year:2017 | Volume:15 | Issue:1 Page(s): 23-35

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Title

EFFECT OF CATECHIN ON SERUM LEVELS OF INFLAMMATORY CYTOKINES, ANTIOXIDANT ENZYMES ACTIVITY AND DNA OXIDATIVE DAMAGE OF OVARIAN TISSUE IN POLYCYSTIC OVARIAN SYNDROME RAT MODEL

Author(s)

Rahbarian Raheleh | SADOUGHI SEYED DAMOON | Issue Writer Certificate

Keywords

POLYCYSTIC OVARIAN SYNDROMEQ2

CATECHINQ2

CYTOKINEQ2

OXIDATIVE STRESSQ2

RATQ2

Abstract

Introduction: Women with polycystic ovary syndrome (PCOS) suffer anovulation due to hormonal disorders, OXIDATIVE STRESS and ovarian tissue inflammation. CATECHIN is the most important green tea flavonoids (Camellia sinensis) with antioxidant properties. This study aimed to determine the effects of CATECHIN on serum levels of inflammatory CYTOKINEs, antioxidant enzymes activity and DNA oxidative damage of ovarian tissue in POLYCYSTIC OVARIAN SYNDROME RAT model.Materials & Methods: In this experimental study, 24 Wistar female RATs were divided into 4 equal groups (n=6) of control (saline solution, 24 days, ip), non-treated PCOS (saline solution, 24 days, ip) and PCOS treated with CATECHIN (50 and 100 mg/kg, 24 days, ip). POLYCYSTIC OVARIAN SYNDROME was induced by single intramuscular injection of estradiol valerate (4 mg/kg). At the end of treatment period, serum levels of TNF-a, IL-1b, IL-6, SOD, CAT, GPX and levels of MDA and HOdG-8 in ovarian tissue were measured by ELISA.Results: Compared to non-treated PCOS group, in treated groups with 50 and 100 mg/kg of CATECHIN, serum levels of TNF-a IL-1b and IL-6 significantly decreased dose-dependently (p<0.05), levels of SOD, CAT, GPX in ovarian tissue significantly increased dose-dependently (p<0.05) and levels of MDA and HOdG-8 significantly decreased dose-dependently (p<0.05).Conclusion: CATECHIN decreases serum levels of CYTOKINEs, increases activity of antioxidant enzymes, decreases lipid peroxidation and DNA oxidative damage of ovarian tissue in POLYCYSTIC OVARIAN SYNDROME RAT model.

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APA: Copy

Rahbarian, Raheleh, & SADOUGHI, SEYED DAMOON. (2017). EFFECT OF CATECHIN ON SERUM LEVELS OF INFLAMMATORY CYTOKINES, ANTIOXIDANT ENZYMES ACTIVITY AND DNA OXIDATIVE DAMAGE OF OVARIAN TISSUE IN POLYCYSTIC OVARIAN SYNDROME RAT MODEL. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 15(1 ), 23-35. SID. https://sid.ir/paper/130935/en

Vancouver: Copy

Rahbarian Raheleh, SADOUGHI SEYED DAMOON. EFFECT OF CATECHIN ON SERUM LEVELS OF INFLAMMATORY CYTOKINES, ANTIOXIDANT ENZYMES ACTIVITY AND DNA OXIDATIVE DAMAGE OF OVARIAN TISSUE IN POLYCYSTIC OVARIAN SYNDROME RAT MODEL. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2017;15(1 ):23-35. Available from: https://sid.ir/paper/130935/en

IEEE: Copy

Raheleh Rahbarian, and SEYED DAMOON SADOUGHI, “EFFECT OF CATECHIN ON SERUM LEVELS OF INFLAMMATORY CYTOKINES, ANTIOXIDANT ENZYMES ACTIVITY AND DNA OXIDATIVE DAMAGE OF OVARIAN TISSUE IN POLYCYSTIC OVARIAN SYNDROME RAT MODEL,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 15, no. 1 , pp. 23–35, 2017, [Online]. Available: https://sid.ir/paper/130935/en

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