EFFECT OF VITAMIN E ON MEMORY DAMAGE INDUCED BY STREPTOZOTOCIN IN ADULT MALE WISTAR RATS

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HOSSEINZADEH FATEMEH; EIDI AKRAM; MORTAZAVI PEJMAN; HAERI ROHANI ALI

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Journal: Qom University of Medical Sciences Journal Year:2017 | Volume:11 | Issue:10 Page(s): 13-20

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Title

EFFECT OF VITAMIN E ON MEMORY DAMAGE INDUCED BY STREPTOZOTOCIN IN ADULT MALE WISTAR RATS

Author(s)

HOSSEINZADEH FATEMEH | EIDI AKRAM | MORTAZAVI PEJMAN | HAERI ROHANI ALI | Issue Writer Certificate

Keywords

MEMORYQ2

STREPTOZOTOCINQ1

VITAMIN EQ2

Abstract

Background and Objectives: VITAMIN E is a nutrient essential for the body. This vitamin as a natural antioxidant, scavenges free radicals in cell membranes and protects unsaturated fatty acids from lipid peroxidation. In the present study, the effect of VITAMIN E on neurodegeneration induced by intracerebroventricular (ICV) administration of STREPTOZOTOCIN (STZ), was investigated in mature adult male Wistar rats.Methods: In this experimental study, the rats were randomly divided into 4 groups of normal control, Alzheimer control rats, and VITAMIN E (100 and 200mg/kg bw, oral daily) together with STZ. The animals received STZ at a dose of 3ml/cannula, 75mg/ml, ICV, bilaterally, on the 1st and 3rd days. VITAMIN E treatment was started 1h before the first dose of STZ and continued for 14 days. Learning and MEMORY behavior was evaluated using passive avoidance test. Data were analyzed by one-factor analysis of variance.Results: STZ treatment decreased step-through latency and increased the time in the dark compartment. Moreover, VITAMIN E treatment attenuated these changes.Conclusion: The results of this research showed that VITAMIN E treatment significantly improves STZ-induced cognitive impairment. Therefore, VITAMIN E can provide protection against aging-induced MEMORY deficit and neuronal damage induced by STZ.

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APA: Copy

HOSSEINZADEH, FATEMEH, EIDI, AKRAM, MORTAZAVI, PEJMAN, & HAERI ROHANI, ALI. (2017). EFFECT OF VITAMIN E ON MEMORY DAMAGE INDUCED BY STREPTOZOTOCIN IN ADULT MALE WISTAR RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 11(10 ), 13-20. SID. https://sid.ir/paper/131934/en

Vancouver: Copy

HOSSEINZADEH FATEMEH, EIDI AKRAM, MORTAZAVI PEJMAN, HAERI ROHANI ALI. EFFECT OF VITAMIN E ON MEMORY DAMAGE INDUCED BY STREPTOZOTOCIN IN ADULT MALE WISTAR RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2017;11(10 ):13-20. Available from: https://sid.ir/paper/131934/en

IEEE: Copy

FATEMEH HOSSEINZADEH, AKRAM EIDI, PEJMAN MORTAZAVI, and ALI HAERI ROHANI, “EFFECT OF VITAMIN E ON MEMORY DAMAGE INDUCED BY STREPTOZOTOCIN IN ADULT MALE WISTAR RATS,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 11, no. 10 , pp. 13–20, 2017, [Online]. Available: https://sid.ir/paper/131934/en

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