MOLECULAR DETECTION OF GENES ENCODING ACRAB, QEP A EFFLUX PUMPS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM HOSPITALIZED PATIENTS IN SELECTED HOSPITALS IN TEHRAN

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HEIDARI MOHSEN; GOUDARZI HOSSEIN; HASHEMI ALI; ESLAMI GITA; KHOSHNOOD SAEED; AMRAEI SHOKOUH

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2017 | Volume:11 | Issue:1 Page(s): 39-48

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Title

MOLECULAR DETECTION OF GENES ENCODING ACRAB, QEP A EFFLUX PUMPS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM HOSPITALIZED PATIENTS IN SELECTED HOSPITALS IN TEHRAN

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Keywords

KLEBSIELLA PNEUMONIAQ1

ACRAB EFFLUX PUMPQ1

FLUOROQUINOLONESQ1

MICROBIAL SENSITIVITY TESTSQ1

Abstract

Background and Objectives: Increasing emergence of fluoroquinolone resistance among clinical isolates of KLEBSIELLA PNEUMONIAe (K. pneumoniae), has limited the treatment options for treatment of infections caused by these bacteria. The aim of this study was to investigate the dissemination of genes encoding AcrAB and QepA efflux pumps among K. pneumoniae strains.Methods: This study was carried out on 117 K. pneumoniae strains isolated from patients hospitalized in selected hospitals in Tehran city, 2015-2016, Iran. Antimicrobial susceptibility tests were performed using disk diffusion method (based on CLSI guidelines) and identification of acr A, acr B and qep A genes using PCR assay.Results: In this study, colistin and tigecycline had the best effect against clinical isolates of K. pneumoniae. According to PCR results, 110 (94%) isolates had acrA gene and 102 (87%) isolates had acrB gene, respectively. The qepA gene was not found in any of the K. pneumoniae strains.Conclusion: According to the results of the present study, dissemination of the genes encoding ACRAB EFFLUX PUMPs among K. pneumoniae strains, which cause resistance to FLUOROQUINOLONES, is a matter of concern. Therefore, infection control and prevention of the spread of drug-resistant bacteria requires careful management in drug prescription and identification of resistant isolates.

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APA: Copy

HEIDARI, MOHSEN, GOUDARZI, HOSSEIN, HASHEMI, ALI, ESLAMI, GITA, KHOSHNOOD, SAEED, & AMRAEI, SHOKOUH. (2017). MOLECULAR DETECTION OF GENES ENCODING ACRAB, QEP A EFFLUX PUMPS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM HOSPITALIZED PATIENTS IN SELECTED HOSPITALS IN TEHRAN. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 11(1), 39-48. SID. https://sid.ir/paper/132003/en

Vancouver: Copy

HEIDARI MOHSEN, GOUDARZI HOSSEIN, HASHEMI ALI, ESLAMI GITA, KHOSHNOOD SAEED, AMRAEI SHOKOUH. MOLECULAR DETECTION OF GENES ENCODING ACRAB, QEP A EFFLUX PUMPS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM HOSPITALIZED PATIENTS IN SELECTED HOSPITALS IN TEHRAN. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2017;11(1):39-48. Available from: https://sid.ir/paper/132003/en

IEEE: Copy

MOHSEN HEIDARI, HOSSEIN GOUDARZI, ALI HASHEMI, GITA ESLAMI, SAEED KHOSHNOOD, and SHOKOUH AMRAEI, “MOLECULAR DETECTION OF GENES ENCODING ACRAB, QEP A EFFLUX PUMPS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM HOSPITALIZED PATIENTS IN SELECTED HOSPITALS IN TEHRAN,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 11, no. 1, pp. 39–48, 2017, [Online]. Available: https://sid.ir/paper/132003/en

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