EFFECT OF VITAMIN B5 ON LIVER ENZYME LEVELS IN BILE DUCT LIGATION CHOLESTATIC RAT MODEL

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EMAMI FATEMEH SADAT; EIDI AKRAM; MORTAZAVI PEJMAN; ASGHARI AHMAD

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2016 | Volume:10 | Issue:10 Page(s): 17-24

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Title

EFFECT OF VITAMIN B5 ON LIVER ENZYME LEVELS IN BILE DUCT LIGATION CHOLESTATIC RAT MODEL

Author(s)

EMAMI FATEMEH SADAT | EIDI AKRAM | MORTAZAVI PEJMAN | ASGHARI AHMAD | Issue Writer Certificate

Keywords

CHOLESTATICQ1

LIVERQ2

RATQ2

PANTOTHENIC ACIDQ1

Abstract

Background and Objectives: Accumulation of toxic bile salts in a bile duct ligation (BDL) animal model plays a pivotal role in the induction of LIVER fibrosis. Vitamin B5 is an essential nutrient, which acts as a cofactor in many detoxification system enzymes. In the present research, the antifibrotic effect of vitamin B5 was investigated on LIVER cholestasis induced by BDL in RATs.Methods: In this experimental study, 72 male Wistar RATs were divided into 9 groups: Control, sham-operated, vitamin B5 (5, 50, and 100 mg/kg bw), BDL, and BDL+vitamin B5 (5, 50, and 100 mg/kg bw).After BDL, RATs were given vitamin B5 via intragastric gavage for 28 consecutive days. At the end of the experiment, blood was collected from heart and activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) enzymes, were measured. The data were analyzed using one-way ANOVA test.Results: In the BDL animals, the serum activities of AST, ALT, and ALP significantly increased (p<0.001). Treatment of BDL RATs with vitamin B5 significantly attenuated these changes.Conclusion: The results of this study indicated that vitamin B5 has hepatoprotective and antifibrotic effects in the CHOLESTATIC LIVER, which is likely due to the antioxidative and free radical scavenging effects of this vitamin.

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APA: Copy

EMAMI, FATEMEH SADAT, EIDI, AKRAM, MORTAZAVI, PEJMAN, & ASGHARI, AHMAD. (2016). EFFECT OF VITAMIN B5 ON LIVER ENZYME LEVELS IN BILE DUCT LIGATION CHOLESTATIC RAT MODEL. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 10(10), 17-24. SID. https://sid.ir/paper/132350/en

Vancouver: Copy

EMAMI FATEMEH SADAT, EIDI AKRAM, MORTAZAVI PEJMAN, ASGHARI AHMAD. EFFECT OF VITAMIN B5 ON LIVER ENZYME LEVELS IN BILE DUCT LIGATION CHOLESTATIC RAT MODEL. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2016;10(10):17-24. Available from: https://sid.ir/paper/132350/en

IEEE: Copy

FATEMEH SADAT EMAMI, AKRAM EIDI, PEJMAN MORTAZAVI, and AHMAD ASGHARI, “EFFECT OF VITAMIN B5 ON LIVER ENZYME LEVELS IN BILE DUCT LIGATION CHOLESTATIC RAT MODEL,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 10, no. 10, pp. 17–24, 2016, [Online]. Available: https://sid.ir/paper/132350/en

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