COMPARISON OF THE EFFECTS OF PREEMPTIVE GABAPENTIN AND DEXTROMETHORPHAN ON THE POSTOPERATIVE PAIN AFTER OPEN PROSTATECTOMY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAGHEGH M.R.; KAVAND B.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2009 | Volume:3 | Issue:2 Page(s): 25-30

Download Full-Text

Persian Verion

View:

873

Download:

Cites:

Information Journal Paper

Title

COMPARISON OF THE EFFECTS OF PREEMPTIVE GABAPENTIN AND DEXTROMETHORPHAN ON THE POSTOPERATIVE PAIN AFTER OPEN PROSTATECTOMY

Author(s)

MOHAGHEGH M.R. | KAVAND B. | Issue Writer Certificate

Keywords

GABAPENTINQ3

DEXTROMETHORPHANQ3

ANESTHESIAQ3

SPINALQ3

ANALGESIAQ3

Abstract

Background and Objectives: Preemptive administration of GABAPENTIN and DEXTROMETHORPHAN has been shown to be effective for reduction of postoperative pain; but the effect of these two drugs has not yet been compared. The aim of the present study was to compare the effects of administration of GABAPENTIN and DEXTROMETHORPHAN on the postoperative pain after open prostatectomy.Methods: In a randomized clinical trial, 80 adult males with ASA class of I, II and III who were candidate for open prostatectomy under SPINAL ANESTHESIA in Shahid Hasheminejad Educational Center (in Tehran) were enrolled and randomly allocated to two groups of GABAPENTIN (n=40) and DEXTROMETHORPHAN (n=40). In DEXTROMETHORPHAN group, 60 mg of DEXTROMETHORPHAN syrup and in GABAPENTIN group, 300 mg of GABAPENTIN syrup were administered 2 hours preoperatively. During operation, the maximum height of block was determined at 5, 10 and 15 minutes after SPINAL ANESTHESIA establishment. In postoperative period, at 1, 2, 12, and 24 hours, the pain intensity was measured through Visual Analogue Pain Scale (VAS); and, overall opioid consumption and the time to first analgesic request were recorded as well.Results: While the pain intensity in all the measurements was comparable between groups, at the 2nd hour, the pain was significantly lesser in GABAPENTIN group (2.70±1.51 vs. 3.74±1.77, P=0.006). Also, the time for the first analgesic request was comparable between study groups; however, the total dose of postoperative opioid consumption was lesser in GABAPENTIN group (45.0±39.32 vs. 64.45±32.12 mg, P=0.018). Moreover, the height of block showed no significant difference.Conclusion: Preemptive oral administration of 300 mg of GABAPENTIN syrup in patients undergoing open prostatectomy under SPINAL ANESTHESIA significantly lessens the pain intensity and the total dose of opioid consumption compared with 60 mg of DEXTROMETHORPHAN syrup. Meanwhile, the level of SPINAL ANESTHESIA and the time for the first analgesic request were comparable between groups.

Cites

No record.

References

No record.

Cite

APA: Copy

MOHAGHEGH, M.R., & KAVAND, B.. (2009). COMPARISON OF THE EFFECTS OF PREEMPTIVE GABAPENTIN AND DEXTROMETHORPHAN ON THE POSTOPERATIVE PAIN AFTER OPEN PROSTATECTOMY. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 3(2), 25-30. SID. https://sid.ir/paper/132409/en

Vancouver: Copy

MOHAGHEGH M.R., KAVAND B.. COMPARISON OF THE EFFECTS OF PREEMPTIVE GABAPENTIN AND DEXTROMETHORPHAN ON THE POSTOPERATIVE PAIN AFTER OPEN PROSTATECTOMY. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2009;3(2):25-30. Available from: https://sid.ir/paper/132409/en

IEEE: Copy

M.R. MOHAGHEGH, and B. KAVAND, “COMPARISON OF THE EFFECTS OF PREEMPTIVE GABAPENTIN AND DEXTROMETHORPHAN ON THE POSTOPERATIVE PAIN AFTER OPEN PROSTATECTOMY,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 3, no. 2, pp. 25–30, 2009, [Online]. Available: https://sid.ir/paper/132409/en

Related Journal Papers