CORRELATION OF HIGH VIRAL BK LOAD IN THE URINE SAMPLES OF PATIENTS WITH GRAFT VERSUS- HOST WITH HAEMORRHAGIC INFECTIOUS DISEASES OF BLADDER AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION

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KOUKHAEI P.; JAZAYERI MOGHADAS A.; SEDIGHI MOGHADAM B.

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Journal: Iranian Journal of Medical Microbiology Year:2007 | Volume:1 | Issue:2 Page(s): 61-66

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Title

CORRELATION OF HIGH VIRAL BK LOAD IN THE URINE SAMPLES OF PATIENTS WITH GRAFT VERSUS- HOST WITH HAEMORRHAGIC INFECTIOUS DISEASES OF BLADDER AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION

Author(s)

KOUKHAEI P. | JAZAYERI MOGHADAS A. | SEDIGHI MOGHADAM B. | Issue Writer Certificate

Keywords

BKVQ4

URINEQ4

HEMATOPOITIC CELLSQ4

GRAFT-VERSUS-HOSTQ4

Abstract

Background and Objectives: A possible temporal correlation between high BK virus (BKV) load in URINE alone or in combination with acute graft versus host disease (GVHD) and the development of hemorrhagic cystitis (HC) was examined in this study.Material and Methods: 31 allergenic hematopoietic stem cell transplanted (SCT) patients were include in this study. BKV DNA was detected by nested and quantitative Real-Time PCR in the URINE of 16 out of 31 patients. HC occurred in 6/16 patients with BKV DNA in their URINE samples. BKV load was evaluated in the URINE samples from 5 of 6 HC patients.Results: Presence of BKV or BKV load> 106 copies alone in URINE samples showed some predictive ability for HC, while acute GVHD alone or conditioning regiments did not. However, during the period after SCT to HC onset a combination of BKV load> 106 copies and acute GVHD, discriminated the best between HC (4/5) and non-HC (2/25) patients (p=0.003).Conclusion: This study indicates that BKV DNA and particularly> 106 BKV copies/ml of URINE from SCT patients may have some predictive ability for HC. However, the best association to HC was achieved when a viral load of> 106 BKV copies/ml of URINE was present in combination with acute GVHD.

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APA: Copy

KOUKHAEI, P., JAZAYERI MOGHADAS, A., & SEDIGHI MOGHADAM, B.. (2007). CORRELATION OF HIGH VIRAL BK LOAD IN THE URINE SAMPLES OF PATIENTS WITH GRAFT VERSUS- HOST WITH HAEMORRHAGIC INFECTIOUS DISEASES OF BLADDER AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 1(2), 61-66. SID. https://sid.ir/paper/132563/en

Vancouver: Copy

KOUKHAEI P., JAZAYERI MOGHADAS A., SEDIGHI MOGHADAM B.. CORRELATION OF HIGH VIRAL BK LOAD IN THE URINE SAMPLES OF PATIENTS WITH GRAFT VERSUS- HOST WITH HAEMORRHAGIC INFECTIOUS DISEASES OF BLADDER AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2007;1(2):61-66. Available from: https://sid.ir/paper/132563/en

IEEE: Copy

P. KOUKHAEI, A. JAZAYERI MOGHADAS, and B. SEDIGHI MOGHADAM, “CORRELATION OF HIGH VIRAL BK LOAD IN THE URINE SAMPLES OF PATIENTS WITH GRAFT VERSUS- HOST WITH HAEMORRHAGIC INFECTIOUS DISEASES OF BLADDER AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 1, no. 2, pp. 61–66, 2007, [Online]. Available: https://sid.ir/paper/132563/en

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