THE STUDY OF HIGH LEVEL GENTAMICIN RESISTANANCE IN ENTEROCOCCUS SPECIES ISOLATED FROM HEALTHY HUMAN IN TEHRAN, 2007-8

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NOUHI NASRIN; TALEBI MALIHEH; EBRAHIMIPOUR GH.H.; POURSHAFIEE M.R.

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2009 | Volume:2 | Issue:3-4 Page(s): 47-52

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Title

THE STUDY OF HIGH LEVEL GENTAMICIN RESISTANANCE IN ENTEROCOCCUS SPECIES ISOLATED FROM HEALTHY HUMAN IN TEHRAN, 2007-8

Author(s)

NOUHI NASRIN | TALEBI MALIHEH | EBRAHIMIPOUR GH.H. | POURSHAFIEE M.R. | Issue Writer Certificate

Keywords

ENTEROCOCCUSQ4

GENTAMICINQ4

HIGH-LEVEL RESISTANCEQ4

HEALTHY HUMANQ4

Abstract

Background and Objective: Enterococci are natural inhabitants of the gastrointestinal tract of humans and animals. Over the past decade, enterococci have become one of the leading causes of nosocomial infections, because they have acquired resistance to many antimicrobial agents such as vancomycin and GENTAMICIN. Development of high-level GENTAMICIN resistance among enterococci represents a serious therapeutic problem as it precludes synergy between aminoglycosides and cell-wall active agents. High-level GENTAMICIN resistance (MIC ³ 500 mg/ml) in enterococci is predominantly mediated by aac (6')-Ie-aph (2”)-Ia. The aim of present study was determination of high level GENTAMICIN resistance in ENTEROCOCCUS species isolated from HEALTHY HUMAN in Tehran.Material and methods: After enrichment of the fecal samples collected from healthy volunteers in BHI broth containing GENTAMICIN, the isolates were subcultured on mENTEROCOCCUS agar containing GENTAMICIN. The isolates were identified to the genus and species levels and MIC was determined. Antibiotic susceptibility of the isolates was tested by agar diffusion for 8 various antibiotics. The aac(6')-Ie-aph(2”)-Ia gene was identified by PCR technique.Results: GENTAMICIN resistant enterococci (GRE) were isolated from 76(15.2%) of 500 fecal samples. The isolated species were: E. faecalis 45(59.2%), E. faecium 29(38.1%) and E. gallinarum 2(2.63%). GRE isolates were highly resistant to GENTAMICIN(MIC ³ 500 mg/ml). Eleven different antimicrobial resistance patterns were observed in this study. All of isolates carried the aac(6')-Ie-aph(2'')-Ia resistance gene.Conclusion: These results represent a rather high prevalence of GENTAMICIN resistance enterococci as a normal flora in the community. The aac(6')-Ie-aph(2'')-Ia gene was the most common gene among the GENTAMICIN-resistant isolates evaluated in this stud.

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APA: Copy

NOUHI, NASRIN, TALEBI, MALIHEH, EBRAHIMIPOUR, GH.H., & POURSHAFIEE, M.R.. (2009). THE STUDY OF HIGH LEVEL GENTAMICIN RESISTANANCE IN ENTEROCOCCUS SPECIES ISOLATED FROM HEALTHY HUMAN IN TEHRAN, 2007-8. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 2(3-4), 47-52. SID. https://sid.ir/paper/132598/en

Vancouver: Copy

NOUHI NASRIN, TALEBI MALIHEH, EBRAHIMIPOUR GH.H., POURSHAFIEE M.R.. THE STUDY OF HIGH LEVEL GENTAMICIN RESISTANANCE IN ENTEROCOCCUS SPECIES ISOLATED FROM HEALTHY HUMAN IN TEHRAN, 2007-8. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2009;2(3-4):47-52. Available from: https://sid.ir/paper/132598/en

IEEE: Copy

NASRIN NOUHI, MALIHEH TALEBI, GH.H. EBRAHIMIPOUR, and M.R. POURSHAFIEE, “THE STUDY OF HIGH LEVEL GENTAMICIN RESISTANANCE IN ENTEROCOCCUS SPECIES ISOLATED FROM HEALTHY HUMAN IN TEHRAN, 2007-8,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 2, no. 3-4, pp. 47–52, 2009, [Online]. Available: https://sid.ir/paper/132598/en

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