IDENTIFICATION OF GENETIC AND PROTEIN MARKERS IN SALMONELLA ENTERICA SEROVAR TYPHIMURIUM BY BIOINFORMATIC ANALYSES FOR THE PURPOSE OF DIAGNOSIS AND TREATMENT

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AMANDADI MOJDEH; RAVAN HADI; HASSANSHAHIAN MEHDI

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2017 | Volume:11 | Issue:4 Page(s): 21-34

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Title

IDENTIFICATION OF GENETIC AND PROTEIN MARKERS IN SALMONELLA ENTERICA SEROVAR TYPHIMURIUM BY BIOINFORMATIC ANALYSES FOR THE PURPOSE OF DIAGNOSIS AND TREATMENT

Author(s)

AMANDADI MOJDEH | RAVAN HADI | HASSANSHAHIAN MEHDI | Issue Writer Certificate

Keywords

SALMONELLA TYPHIMURIUMQ2

SPECIFIC MARKERSQ2

PROTEIN STRUCTURE MODELINGQ2

Abstract

Background and Aims: Salmonella enterica serovar Typhimurium is one of the common causes of food poisoning in human. Since the selection of appropriate markers is one of the main challenges for the detection of this pathogen, in the current study, genetic markers of this serovar were screened using bioinformatical tools. In the second phase, structure and function of proteins encoded by these markers, were determined.Materials and Methods: This study was conducted between 2016 and 2017. In order to find the genetic markers ofSalmonella enterica serovar Typhimurium, 45 complete genomes belonging toSalmonella enterica serovar Typhimurium and the other genera of Enterobacteriaceafamily were compared using Mauve software. To determine the structure and function of proteins encoded by these sequences, I-TASSER and Phyre2 software beside CDD, Inter Pro Scan, DALI, and Pro Func databases were used for structural and functional modeling, respectively.Results: Special regions of STM4491 - STM4496 genes were determined as SPECIFIC MARKERS forSalmonella enterica serovar Typhimurium. The function of proteins encoded by these markers were proposed to be classified in five groups, including Lon protease, nucleotide binding proteins, nucleotide three phosphatases (NTP), proteins involved in the DNA repair, and DNA methylase.Conclusions: Specific regions of STM4491 - STM4496 genes can be used as effective diagnostic targets for the detection of pathogenicSalmonella enterica serovar Typhimurium.Moreover, proteins encoded by these genes can be suggested as suitable targets for the design of new therapeutic agents to prevent and treat the infections caused by this pathogen.

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APA: Copy

AMANDADI, MOJDEH, RAVAN, HADI, & HASSANSHAHIAN, MEHDI. (2017). IDENTIFICATION OF GENETIC AND PROTEIN MARKERS IN SALMONELLA ENTERICA SEROVAR TYPHIMURIUM BY BIOINFORMATIC ANALYSES FOR THE PURPOSE OF DIAGNOSIS AND TREATMENT. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 11(4), 21-34. SID. https://sid.ir/paper/132672/en

Vancouver: Copy

AMANDADI MOJDEH, RAVAN HADI, HASSANSHAHIAN MEHDI. IDENTIFICATION OF GENETIC AND PROTEIN MARKERS IN SALMONELLA ENTERICA SEROVAR TYPHIMURIUM BY BIOINFORMATIC ANALYSES FOR THE PURPOSE OF DIAGNOSIS AND TREATMENT. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2017;11(4):21-34. Available from: https://sid.ir/paper/132672/en

IEEE: Copy

MOJDEH AMANDADI, HADI RAVAN, and MEHDI HASSANSHAHIAN, “IDENTIFICATION OF GENETIC AND PROTEIN MARKERS IN SALMONELLA ENTERICA SEROVAR TYPHIMURIUM BY BIOINFORMATIC ANALYSES FOR THE PURPOSE OF DIAGNOSIS AND TREATMENT,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 11, no. 4, pp. 21–34, 2017, [Online]. Available: https://sid.ir/paper/132672/en

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