Synthesis, Characterizations, Biological Activity and Molecular Docking Study of New Azo Schiff-Bases

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Saad Mahdi Dalia; Wahed Naser Ahmed

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Journal Paper

Paper Information

Journal: ADVANCED JOURNAL OF CHEMISTRY, SECTION A Year:2024 | Volume:7 | Issue:6 Page(s): 842-852

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Information Journal Paper

Title

Synthesis, Characterizations, Biological Activity and Molecular Docking Study of New Azo Schiff-Bases

Author(s)

Saad Mahdi Dalia | Wahed Naser Ahmed | Issue Writer Certificate

Keywords

Schiff base

Azo Dyes

Molecular docking

Antimicrobial

Antifungal

Abstract

A new Schiff base (5) was synthesized by reacting the hydrazide derivative (3) with p-aminoacetophenone in the presence of a few drops of H2SO4 in ethanol as a solvent. Following this preparation, the diazonium salt was prepared by reacting compound (6) with sodium nitrate in the presence of HCl at 0-5 °C and performing a coupling reaction. This reaction involved the prepared diazonium salt and some substituted phenols, leading to the formation of the corresponding azo-Schiff bases 7(a–e). Target compounds were identified using FT-IR, 1H-NMR and 13C-NMR. The second part of the current work includes the investigation of molecular docking and biological activities such as antimicrobial and antifungal effects.

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