Western Diet and Cognitive Impairment: Links to Potential Mechanisms: A Review

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Aslan Betul

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Journal Paper

Paper Information

Journal: International Journal of Nutrition Sciences Year:2023 | Volume:8 | Issue:3 Page(s): 131-143

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Information Journal Paper

Title

Western Diet and Cognitive Impairment: Links to Potential Mechanisms: A Review

Author(s)

Aslan Betul | Issue Writer Certificate

Keywords

Western dietQ4

Cognitive FunctionsQ4

LearningQ4

MemoryQ4

NeuroinflammationQ4

Abstract

Animal studies in recent years have shown that a Western diet style (WD-style) which is high in saturated fat and refined carbohydrates causes obesity, metabolic syndrome and cardiovascular diseases. In addition, results demonstrated that it can damage the structures that make up the nervous system. Accordingly, there is an evidence that systemic changes associated with the Western diet lead to blood-brain barrier (BBB) disruption, microglia activation, and the development of Neuroinflammation. These changes are then followed by synaptic transmission dysfunction, neurodegeneration, and finally Memory and cognitive deterioration. This review summarizes research on the mechanisms that show Western diet consumption is associated with cognitive impairment, with emphasis on Learning and Memory functions that depend on the integrity of the hippocampus.

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