Clinically amyopathic dermatomyositis during the COVID-19 pandemic (Case Report)

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Raone Beatrice; Viviani Filippo; Fusconi Marco; Muratori Luigi

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Journal Paper

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Journal: Iranian Journal of Dermatology Year:2023 | Volume:26 | Issue:4 Page(s): 232-236

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Information Journal Paper

Title

Clinically amyopathic dermatomyositis during the COVID-19 pandemic (Case Report)

Author(s)

Raone Beatrice | Viviani Filippo | Fusconi Marco | Muratori Luigi | Issue Writer Certificate

Keywords

COVID-19

SARS-CoV-2

clinically amyopathic dermatomyositis

anti-MDA5

Abstract

We report a case of clinically amyopathic dermatomyositis (CADM) with anti-MDA5 positivity associated with rapidly progressive interstitial lung disease. The analogies between CADM-associated interstitial lung disease and coronavirus disease 2019 (COVID-19) pneumonia may hinder the diagnosis and delay the start of immunosuppressive therapy. High-resolution computed tomography revealed an evident worsening of the bilateral consolidation, interlobular septal thickening, and ground-glass opacities, highlighting the diagnosis of rapidly progressive interstitial lung disease. The radiological presentation, combined with the laboratory findings, underscored the diagnosis of CADM. In the following days, the respiratory failure progressed, and the patient required extracorporeal membrane oxygenation and lung transplantation. The typical cutaneous rash of dermatomyositis and non-pulmonary clinical differences can help the physician reach a correct diagnosis. Assessing patients with interstitial lung diseases during the COVID-19 pandemic is difficult. Through experience with systemic autoimmune diseases such as clinically amyopathic dermatomyositis, we can develop new pathophysiology models and therapeutic strategies for COVID-19.

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