Investigating the Hepcidin Gene Polymorphisms in COVID-19-Associated Mucormycosis Susceptibility: A Clinical-Laboratory Study

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Ravanbakhsh Reyhaneh; Farhand Yalda; Ravanbakhsh Ghavghani Fatemeh

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Medical Sciences Year:2024 | Volume:49 | Issue:7 Page(s): 450-460

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Investigating the Hepcidin Gene Polymorphisms in COVID-19-Associated Mucormycosis Susceptibility: A Clinical-Laboratory Study

Author(s)

Ravanbakhsh Reyhaneh | Farhand Yalda | Ravanbakhsh Ghavghani Fatemeh | Issue Writer Certificate

Keywords

COVID-19Q4

HepcidinQ4

MucormycosisQ4

PolymorphismQ4

Single NucleotideQ4

Abstract

Background: Following the coronavirus disease 2019 outbreak (COVID-19), it became a worrisome health burden worldwide. COVID-19-associated Mucormycosis emergence, characterized by dysregulated inflammation and iron metabolism, exacerbated the prognosis of affected patients. Given the significance of Hepcidin in regulating inflammation and iron metabolism, this study investigated the significance of Hepcidin Single Nucleotide Polymorphisms (SNP) in COVID-19-associated Mucormycosis development, along with the association between the clinical and laboratory factors and COVID-19-associated Mucormycosis. Methods: From September 2021 to November 2021, COVID-19 patients with and without Mucormycosis were enrolled in this cross-sectional study. Their medical records and laboratory results were investigated. SNP genotyping was performed using Sanger sequencing. Hardy-Weinberg Equilibrium, Pearson’s Chi square, and student t test were used for analyzing the data using SPSS software version 25. P<0.05 was regarded as statistically significant.Results: Here, 110 COVID-19 patients with and without Mucormycosis were investigated. Elevated levels of urea, aspartate aminotransferase, lactate dehydrogenase, and increased ratio of polymorphonuclear neutrophil to lymphocytes were associated with decreased risk of COVID-19-associated Mucormycosis in patients (all P<0.05). Moreover, diabetes mellitus increased the risk of Mucormycosis (P=0.028). In contrast to patients without Mucormycosis, patients with Mucormycosis did not display 442 GA and SNP335 GT genotypes. Unlike patients without Mucormycosis, none of the patients with Mucormycosis had SNP442 GA and SNP335 GT genotypes. Regarding SNP 443 C>T, and the combination of SNPs 582 A>G and 443 C>T, CC genotype and AA+CC genotypes were associated with increased lactate dehydrogenase levels in COVID-19 patients, respectively. Conclusion: Regarding SNP 443 C>T, the CC genotype was associated with increased lactate dehydrogenase levels in COVID-19 patients. In terms of SNP 582 A>G and SNP 443 C>T, COVID-19 patients with AA+CC genotypes had higher levels of LDH. None of the patients with Mucormycosis had SNP442 GA and SNP335 GT genotypes.

Cites

No record.

References