The Effect of Vitamin C on Ischemia-Reperfusion Injury: A Systematic Review

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Masmouei Behnam; Zarei Ali; Kouhi Habibi Dehkordi Shamim; Raisi Mahmood; Rasekh Fatemeh; Rafi Bazrafshan Mohammad; Parviniannasab Ali Mohammad; Firooz Mohajan Abadi Reza; Hamidi zadeh Saeed

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Journal Paper

Paper Information

Journal: Journal of Iranian Medical Council Year:621 | Volume: | Issue: Page(s): 200-222

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Information Journal Paper

Title

The Effect of Vitamin C on Ischemia-Reperfusion Injury: A Systematic Review

Author(s)

Keywords

Ascorbic acidQ4

IschemiaQ4

Reperfusion injuryQ4

Abstract

AbstractIschemia is one of the most common injuries that is usually caused by reduced blood flow to the tissues. Following this incident, the tissue becomes deficient in oxygen and nutrients, and energy production in the affected cells stops, eventually leading to cell damage, but there is also evidence that restoring blood flow to ischemic tissues can lead to extra tissue damage known as Ischemia Reperfusion injury (IRI). In this study, we reviewed the relationship between vitamin C intake and Ischemia/reperfusion injury to investigate the relationship between vitamin C intake and Ischemia/reperfusion injury. The keywords “Vitamin C” or “Ascorbic acid” and “Ischemic” or “Ischemia” and “Reperfusion” were used in this search. The results show that vitamin C has a positive effect on Ischemia treatment in the renal tissue, brain, liver, intestine, lung, ovary, pancreas, and skin.

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