Molecular Characterization and Metastatic Gene Signatures Based on Targeted Cancer Treatment Modalities

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El Khatib Sami

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Journal Paper

Paper Information

Journal: MIDDLE EAST JOURNAL OF CANCER Year:2024 | Volume:15 | Issue:2 Page(s): 87-88

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Information Journal Paper

Title

Molecular Characterization and Metastatic Gene Signatures Based on Targeted Cancer Treatment Modalities

Author(s)

El Khatib Sami | Issue Writer Certificate

Keywords

Cancer Biology

Metastasis

Gene Signature

Targeted Medicine

Abstract

Despite being the hallmark of the illness and being responsible for up to 90% of cancer-related deaths, Metastasis is the part of cancer pathophysiology that is least understood.1 Cancer cells can infiltrate, settle, and colonize through their interaction with the tumor microenvironment (TME), which facilitates their passage through stromal barriers. The initial tumor persists and extravasates into the parenchyma of distant tissues throughout the vascular walls after intravasation into the surrounding tissues via the lymphatic and blood system's microvasculature. This invasiveness encourages the formation of micro-metastatic colonies by cancer cells in the parenchyma, which eventually grow to produce overt, clinically apparent metastatic lesions (colonization)...

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