Comparison of the Effect of a Course of Resistance and Endurance Training with Ursolic Acid Consumption on the Levels of Fetoin-A and B in the Liver Tissue of Elderly Male Diabetic Rats

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Bagheri Laleh; Faramarzi Mohammad; Hemati Farsani Zahra; Hossein zadeh Masoumeh

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Journal Paper

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Journal: Iranian Journal of Diabetes and Metabolism Year:2023 | Volume: | Issue: Page(s): 398-408

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Title

Comparison of the Effect of a Course of Resistance and Endurance Training with Ursolic Acid Consumption on the Levels of Fetoin-A and B in the Liver Tissue of Elderly Male Diabetic Rats

Author(s)

Bagheri Laleh | Faramarzi Mohammad | Hemati Farsani Zahra | Hossein zadeh Masoumeh | Issue Writer Certificate

Keywords

Fetuin AQ4

Fetuin BQ4

Ursolic AcidQ4

ExerciseQ4

Abstract

2Background: Fetoin-A and-B are hepatokines that are related to type 2 diabetes. The aim of the present study was to investigate the effect of a period of resistance and endurance training with Ursolic Acid consumption on the levels of Fetoin-A and-B in the liver tissue of elderly diabetics. Methods: Fifty six 21-month-old male diabetic rats were randomly divided into seven equal groups of control (C), Ursolic Acid supplement (UA), supplement+resistance Exercise (UA+R), supplement+endurance Exercise (UA+E), Resistance training (R), endurance training (E) and sham group (D). Resistance training protocol with intensity of 60% MVCC, 14-20 times of ladder climbing with one minute rest between each effort and endurance training including running on Treadmill at high intensity 60-75% and low intensity 30-40% of maximum speed for five days per week for eight weeks. Supplemented groups received 500 mg/kg UA in combination with a high-fat meal. Results: Fetoin-A level was significantly decreased in UA, E, UA+E groups (p≤0. 05) and only in R and UA+R groups, there was no significant decrease. Also, The amount of Fetoin-B in diabetic rats in the UA, E, R, UA+E groups decreased significantly (p≤0. 05) and only in the UA+R training group there were no significant changes. The amount of Fetoin-A and Fetoin-B was significantly different between E and R and UA+R and UA+E groups (p≤0. 05), which the largest decrease was in the UA+E group. Conclusion: Considering the beneficial effects of Exercise training as well as UA supplementation on hepatokines, it seems that the simultaneous application of two interventions of Exercise training and UA supplementation has a more therapeutic effect on the hepatic hepatokines of diabetics

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